| | Tahlequah, OK | Muskogee, OK | United States |
| Population | 16,213 | 37,214 | 329,725,481 |
| Female Population | 53.6% | 51.2% | 50.5% |
| Male Population | 46.4% | 48.8% | 49.5% |
| Median Age | 30.2 | 35.4 | 38.4 |
| space3 | | | |
| Population - 2010 | 15,771 | 39,241 | 309,327,143 |
| Population - 2000 | 14,458 | 38,310 | 285,036,114 |
| Population - 1990 | 10,398 | 37,708 | 251,960,433 |
| Pop. 2000 to Now | 17.6% | -3.9% | 15.6% |
| Pop. 1990 to Now | 63.5% | -2.3% | 30.8% |
| space4 | | | |
| Population Density | 1,299.0 | 862.2 | 93.4 |
| Land Area | 12.5 | 43.2 | 3,531,905.4 |
| Water Area | 0.0 | 1.6 | 264,836.8 |
| space | | | |
| Est. Total Population By Age | | | |
| | Tahlequah, OK | Muskogee, OK | United States |
| Age 0 to 4 | 5.6% | 7.3% | 5.9% |
| Age 5 to 9 | 4.7% | 7.1% | 6.1% |
| Age 10 to 14 | 5.7% | 7.8% | 6.6% |
| Age 15 to 17 | 3.9% | 4.4% | 3.9% |
| Age 18 to 20 | 10.5% | 4.3% | 4.0% |
| Age 21 to 24 | 13.1% | 5.6% | 5.2% |
| Age 25 to 34 | 11.8% | 13.2% | 13.8% |
| Age 35 to 44 | 12.7% | 11.7% | 12.9% |
| Age 45 to 54 | 9.3% | 11.4% | 12.6% |
| Age 55 to 59 | 3.6% | 6.0% | 6.7% |
| Age 60 to 64 | 4.0% | 6.4% | 6.3% |
| Age 65 to 74 | 7.9% | 8.6% | 9.6% |
| Age 75 to 84 | 4.7% | 4.5% | 4.5% |
| Age 85 and over | 2.6% | 1.8% | 1.9% |
| space1 | | | |
| Race | | | |
| | Tahlequah, OK | Muskogee, OK | United States |
| White | 45.9% | 49.4% | 59.4% |
| Black | 2.2% | 15.0% | 12.2% |
| Asian | 1.4% | 0.9% | 5.6% |
| Native American | 29.4% | 15.1% | 0.6% |
| Hawaiian, Pacific Islander | 0.0% | 0.0% | 0.2% |
| Other | 0.0% | 0.2% | 0.4% |
| Two or More Races | 11.7% | 11.2% | 3.2% |
| Hispanic | 9.4% | 8.3% | 18.4% |
| space2 | | | |
| Marriage & Family | | | |
| | Tahlequah, OK | Muskogee, OK | United States |
| Married Population | 38.4% | 44.2% | 49.8% |
| Currently Married | 37.2% | 41.2% | 48.0% |
| Married but Separated | 1.2% | 3.0% | 1.8% |
| Single Population | 61.6% | 55.8% | 50.2% |
| Never Married | 42.3% | 32.8% | 33.8% |
| Divorced | 11.0% | 15.0% | 10.8% |
| Widowed | 8.3% | 8.1% | 5.6% |
| space5 | | | |
| Household Size | 2.38 | 2.49 | 2.60 |
| Households | 6,169 | 14,418 | 124,010,992 |
| Family Households | 3,330 | 9,015 | 80,755,759 |
| Married couple, w/children | 27.2% | 25.8% | 30.5% |
| Married couple, no children | 41.5% | 36.5% | 42.9% |
| Non Family Households | 2,839 | 5,403 | 43,255,233 |
| Single householder, w/children | 18.7% | 27.7% | 15.8% |
| Single householder, no children | 12.6% | 10.0% | 10.8% |