| | Caruthersville, MO | Holland, MO | United States |
| Population | 5,606 | 123 | 329,725,481 |
| Female Population | 55.9% | 49.6% | 50.5% |
| Male Population | 44.2% | 50.4% | 49.5% |
| Median Age | 36.2 | 60.1 | 38.4 |
| space3 | | | |
| Population - 2010 | 6,124 | 229 | 309,327,143 |
| Population - 2000 | 6,760 | 246 | 285,036,114 |
| Population - 1990 | 7,389 | 237 | 251,960,433 |
| Pop. 2000 to Now | -21.8% | -21.5% | 15.6% |
| Pop. 1990 to Now | -28.4% | -18.6% | 30.8% |
| space4 | | | |
| Population Density | 1,087.1 | 736.5 | 93.4 |
| Land Area | 5.2 | 0.2 | 3,531,905.4 |
| Water Area | 0.1 | 0.0 | 264,836.8 |
| space | | | |
| Est. Total Population By Age | | | |
| | Caruthersville, MO | Holland, MO | United States |
| Age 0 to 4 | 6.5% | 1.6% | 5.9% |
| Age 5 to 9 | 6.2% | 2.4% | 6.1% |
| Age 10 to 14 | 8.7% | 0.8% | 6.6% |
| Age 15 to 17 | 4.2% | 0.8% | 3.9% |
| Age 18 to 20 | 6.6% | 4.9% | 4.0% |
| Age 21 to 24 | 2.9% | 3.3% | 5.2% |
| Age 25 to 34 | 12.8% | 10.6% | 13.8% |
| Age 35 to 44 | 12.4% | 1.6% | 12.9% |
| Age 45 to 54 | 12.8% | 18.7% | 12.6% |
| Age 55 to 59 | 7.1% | 3.3% | 6.7% |
| Age 60 to 64 | 6.0% | 26.8% | 6.3% |
| Age 65 to 74 | 8.6% | 17.1% | 9.6% |
| Age 75 to 84 | 4.2% | 5.7% | 4.5% |
| Age 85 and over | 0.9% | 2.4% | 1.9% |
| space1 | | | |
| Race | | | |
| | Caruthersville, MO | Holland, MO | United States |
| White | 55.5% | 85.4% | 59.4% |
| Black | 40.6% | 7.3% | 12.2% |
| Asian | 0.0% | 0.0% | 5.6% |
| Native American | 0.3% | 0.0% | 0.6% |
| Hawaiian, Pacific Islander | 0.0% | 0.0% | 0.2% |
| Other | 0.0% | 0.0% | 0.4% |
| Two or More Races | 0.4% | 7.3% | 3.2% |
| Hispanic | 3.2% | 0.0% | 18.4% |
| space2 | | | |
| Marriage & Family | | | |
| | Caruthersville, MO | Holland, MO | United States |
| Married Population | 35.0% | 69.2% | 49.8% |
| Currently Married | 30.0% | 59.0% | 48.0% |
| Married but Separated | 5.0% | 10.3% | 1.8% |
| Single Population | 65.0% | 30.8% | 50.2% |
| Never Married | 41.9% | 11.1% | 33.8% |
| Divorced | 16.4% | 7.7% | 10.8% |
| Widowed | 6.7% | 12.0% | 5.6% |
| space5 | | | |
| Household Size | 2.61 | 1.81 | 2.60 |
| Households | 2,116 | 68 | 124,010,992 |
| Family Households | 1,248 | 40 | 80,755,759 |
| Married couple, w/children | 17.8% | 5.0% | 30.5% |
| Married couple, no children | 32.2% | 85.0% | 42.9% |
| Non Family Households | 868 | 28 | 43,255,233 |
| Single householder, w/children | 25.6% | 5.0% | 15.8% |
| Single householder, no children | 24.4% | 5.0% | 10.8% |