| | Depew, NY | Mettawa, IL | United States |
| Population | 15,188 | 647 | 329,725,481 |
| Female Population | 53.8% | 57.7% | 50.5% |
| Male Population | 46.2% | 42.4% | 49.5% |
| Median Age | 41.6 | 48.8 | 38.4 |
| space3 | | | |
| Population - 2010 | 15,432 | 539 | 309,327,143 |
| Population - 2000 | 16,629 | 367 | 285,036,114 |
| Population - 1990 | 17,673 | 348 | 251,960,433 |
| Pop. 2000 to Now | -10.2% | 48.8% | 15.6% |
| Pop. 1990 to Now | -15.5% | 56.9% | 30.8% |
| space4 | | | |
| Population Density | 2,992.1 | 124.3 | 93.4 |
| Land Area | 5.1 | 5.2 | 3,531,905.4 |
| Water Area | 0.0 | 0.1 | 264,836.8 |
| space | | | |
| Est. Total Population By Age | | | |
| | Depew, NY | Mettawa, IL | United States |
| Age 0 to 4 | 5.2% | 4.2% | 5.9% |
| Age 5 to 9 | 6.2% | 8.2% | 6.1% |
| Age 10 to 14 | 6.6% | 6.2% | 6.6% |
| Age 15 to 17 | 2.6% | 6.3% | 3.9% |
| Age 18 to 20 | 2.4% | 3.4% | 4.0% |
| Age 21 to 24 | 3.7% | 3.1% | 5.2% |
| Age 25 to 34 | 15.6% | 1.9% | 13.8% |
| Age 35 to 44 | 11.3% | 8.5% | 12.9% |
| Age 45 to 54 | 12.9% | 22.4% | 12.6% |
| Age 55 to 59 | 7.7% | 6.2% | 6.7% |
| Age 60 to 64 | 6.5% | 8.2% | 6.3% |
| Age 65 to 74 | 12.3% | 16.2% | 9.6% |
| Age 75 to 84 | 5.2% | 3.2% | 4.5% |
| Age 85 and over | 1.7% | 2.0% | 1.9% |
| space1 | | | |
| Race | | | |
| | Depew, NY | Mettawa, IL | United States |
| White | 90.2% | 86.4% | 59.4% |
| Black | 4.2% | 2.6% | 12.2% |
| Asian | 0.4% | 3.1% | 5.6% |
| Native American | 0.1% | 0.0% | 0.6% |
| Hawaiian, Pacific Islander | 0.0% | 0.0% | 0.2% |
| Other | 0.0% | 0.0% | 0.4% |
| Two or More Races | 1.9% | 0.9% | 3.2% |
| Hispanic | 3.2% | 7.0% | 18.4% |
| space2 | | | |
| Marriage & Family | | | |
| | Depew, NY | Mettawa, IL | United States |
| Married Population | 48.8% | 62.6% | 49.8% |
| Currently Married | 47.3% | 61.1% | 48.0% |
| Married but Separated | 1.5% | 1.5% | 1.8% |
| Single Population | 51.2% | 37.4% | 50.2% |
| Never Married | 28.5% | 22.6% | 33.8% |
| Divorced | 13.7% | 8.5% | 10.8% |
| Widowed | 9.0% | 6.3% | 5.6% |
| space5 | | | |
| Household Size | 2.31 | 2.85 | 2.60 |
| Households | 6,538 | 227 | 124,010,992 |
| Family Households | 4,108 | 170 | 80,755,759 |
| Married couple, w/children | 21.1% | 35.3% | 30.5% |
| Married couple, no children | 47.0% | 52.4% | 42.9% |
| Non Family Households | 2,430 | 57 | 43,255,233 |
| Single householder, w/children | 19.7% | 7.6% | 15.8% |
| Single householder, no children | 12.3% | 4.7% | 10.8% |