| | Durham, NC | Santa Clara, CA | United States |
| Population | 279,106 | 127,922 | 329,725,481 |
| Female Population | 52.9% | 47.8% | 50.5% |
| Male Population | 47.1% | 52.2% | 49.5% |
| Median Age | 34.6 | 34 | 38.4 |
| space3 | | | |
| Population - 2010 | 231,586 | 116,857 | 309,327,143 |
| Population - 2000 | 187,035 | 102,361 | 285,036,114 |
| Population - 1990 | 136,611 | 93,613 | 251,960,433 |
| Pop. 2000 to Now | 52.9% | 28.0% | 15.6% |
| Pop. 1990 to Now | 109.3% | 40.0% | 30.8% |
| space4 | | | |
| Population Density | 2,488.1 | 6,952.7 | 93.4 |
| Land Area | 112.2 | 18.4 | 3,531,905.4 |
| Water Area | 0.9 | 0.0 | 264,836.8 |
| space | | | |
| Est. Total Population By Age | | | |
| | Durham, NC | Santa Clara, CA | United States |
| Age 0 to 4 | 6.4% | 6.6% | 5.9% |
| Age 5 to 9 | 5.7% | 5.6% | 6.1% |
| Age 10 to 14 | 5.5% | 4.2% | 6.6% |
| Age 15 to 17 | 3.3% | 2.8% | 3.9% |
| Age 18 to 20 | 5.0% | 4.8% | 4.0% |
| Age 21 to 24 | 6.0% | 5.5% | 5.2% |
| Age 25 to 34 | 19.1% | 22.4% | 13.8% |
| Age 35 to 44 | 14.0% | 15.6% | 12.9% |
| Age 45 to 54 | 11.9% | 11.6% | 12.6% |
| Age 55 to 59 | 5.6% | 5.5% | 6.7% |
| Age 60 to 64 | 5.4% | 4.5% | 6.3% |
| Age 65 to 74 | 7.7% | 5.9% | 9.6% |
| Age 75 to 84 | 3.3% | 3.4% | 4.5% |
| Age 85 and over | 1.3% | 1.5% | 1.9% |
| space1 | | | |
| Race | | | |
| | Durham, NC | Santa Clara, CA | United States |
| White | 40.6% | 30.2% | 59.4% |
| Black | 36.7% | 2.7% | 12.2% |
| Asian | 5.3% | 45.7% | 5.6% |
| Native American | 0.2% | 0.1% | 0.6% |
| Hawaiian, Pacific Islander | 0.1% | 0.7% | 0.2% |
| Other | 0.3% | 0.4% | 0.4% |
| Two or More Races | 3.5% | 4.3% | 3.2% |
| Hispanic | 13.2% | 15.8% | 18.4% |
| space2 | | | |
| Marriage & Family | | | |
| | Durham, NC | Santa Clara, CA | United States |
| Married Population | 42.9% | 53.3% | 49.8% |
| Currently Married | 40.7% | 51.7% | 48.0% |
| Married but Separated | 2.2% | 1.6% | 1.8% |
| Single Population | 57.1% | 46.7% | 50.2% |
| Never Married | 43.1% | 37.0% | 33.8% |
| Divorced | 9.9% | 6.4% | 10.8% |
| Widowed | 4.1% | 3.2% | 5.6% |
| space5 | | | |
| Household Size | 2.27 | 2.68 | 2.60 |
| Households | 117,638 | 45,830 | 124,010,992 |
| Family Households | 64,953 | 30,055 | 80,755,759 |
| Married couple, w/children | 27.4% | 38.7% | 30.5% |
| Married couple, no children | 39.4% | 42.1% | 42.9% |
| Non Family Households | 52,685 | 15,775 | 43,255,233 |
| Single householder, w/children | 20.7% | 8.3% | 15.8% |
| Single householder, no children | 12.4% | 11.0% | 10.8% |