| | Estero, FL | Sikeston, MO | United States |
| Population | 36,187 | 16,054 | 329,725,481 |
| Female Population | 51.4% | 52.6% | 50.5% |
| Male Population | 48.6% | 47.4% | 49.5% |
| Median Age | 65.4 | 37.8 | 38.4 |
| space3 | | | |
| Population - 2010 | 28,070 | 16,347 | 309,327,143 |
| Population - 2000 | 9,503 | 16,992 | 285,036,114 |
| Population - 1990 | 3,177 | 17,641 | 251,960,433 |
| Pop. 2000 to Now | 261.8% | -6.0% | 15.6% |
| Pop. 1990 to Now | 982.3% | -9.5% | 30.8% |
| space4 | | | |
| Population Density | 1,480.2 | 918.9 | 93.4 |
| Land Area | 24.4 | 17.5 | 3,531,905.4 |
| Water Area | 0.9 | 0.2 | 264,836.8 |
| space | | | |
| Est. Total Population By Age | | | |
| | Estero, FL | Sikeston, MO | United States |
| Age 0 to 4 | 2.5% | 7.6% | 5.9% |
| Age 5 to 9 | 3.0% | 7.5% | 6.1% |
| Age 10 to 14 | 3.4% | 5.8% | 6.6% |
| Age 15 to 17 | 1.9% | 3.5% | 3.9% |
| Age 18 to 20 | 0.9% | 2.1% | 4.0% |
| Age 21 to 24 | 1.8% | 4.4% | 5.2% |
| Age 25 to 34 | 6.4% | 15.4% | 13.8% |
| Age 35 to 44 | 6.0% | 9.8% | 12.9% |
| Age 45 to 54 | 7.6% | 9.4% | 12.6% |
| Age 55 to 59 | 5.7% | 6.5% | 6.7% |
| Age 60 to 64 | 10.0% | 5.6% | 6.3% |
| Age 65 to 74 | 27.4% | 10.7% | 9.6% |
| Age 75 to 84 | 18.7% | 9.0% | 4.5% |
| Age 85 and over | 4.7% | 2.5% | 1.9% |
| space1 | | | |
| Race | | | |
| | Estero, FL | Sikeston, MO | United States |
| White | 86.7% | 66.5% | 59.4% |
| Black | 1.5% | 24.2% | 12.2% |
| Asian | 2.7% | 0.8% | 5.6% |
| Native American | 0.1% | 0.0% | 0.6% |
| Hawaiian, Pacific Islander | 0.1% | 0.0% | 0.2% |
| Other | 0.1% | 0.0% | 0.4% |
| Two or More Races | 0.7% | 5.4% | 3.2% |
| Hispanic | 8.2% | 3.0% | 18.4% |
| space2 | | | |
| Marriage & Family | | | |
| | Estero, FL | Sikeston, MO | United States |
| Married Population | 69.0% | 47.9% | 49.8% |
| Currently Married | 68.3% | 46.0% | 48.0% |
| Married but Separated | 0.8% | 1.9% | 1.8% |
| Single Population | 31.0% | 52.1% | 50.2% |
| Never Married | 13.0% | 30.7% | 33.8% |
| Divorced | 10.7% | 12.6% | 10.8% |
| Widowed | 7.3% | 8.8% | 5.6% |
| space5 | | | |
| Household Size | 2.09 | 2.30 | 2.60 |
| Households | 17,289 | 6,846 | 124,010,992 |
| Family Households | 11,752 | 4,199 | 80,755,759 |
| Married couple, w/children | 12.4% | 25.0% | 30.5% |
| Married couple, no children | 80.6% | 41.6% | 42.9% |
| Non Family Households | 5,537 | 2,647 | 43,255,233 |
| Single householder, w/children | 3.8% | 24.8% | 15.8% |
| Single householder, no children | 3.2% | 8.6% | 10.8% |