| | Holliston, MA | Portland, ME | United States |
| Population | 14,891 | 68,063 | 329,725,481 |
| Female Population | 50.0% | 51.2% | 50.5% |
| Male Population | 50.0% | 48.9% | 49.5% |
| Median Age | 44.2 | 36.9 | 38.4 |
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| Population - 2010 | 13,584 | 66,089 | 309,327,143 |
| Population - 2000 | 13,801 | 64,249 | 285,036,114 |
| Population - 1990 | 12,926 | 64,358 | 251,960,433 |
| Pop. 2000 to Now | 7.8% | 4.0% | 15.6% |
| Pop. 1990 to Now | 15.1% | 3.8% | 30.8% |
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| Population Density | 798.7 | 3,155.6 | 93.4 |
| Land Area | 18.6 | 21.6 | 3,531,905.4 |
| Water Area | 0.4 | 47.9 | 264,836.8 |
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| Est. Total Population By Age | | | |
| | Holliston, MA | Portland, ME | United States |
| Age 0 to 4 | 4.3% | 4.9% | 5.9% |
| Age 5 to 9 | 6.7% | 4.4% | 6.1% |
| Age 10 to 14 | 7.7% | 4.5% | 6.6% |
| Age 15 to 17 | 4.7% | 2.1% | 3.9% |
| Age 18 to 20 | 2.1% | 2.7% | 4.0% |
| Age 21 to 24 | 4.4% | 6.4% | 5.2% |
| Age 25 to 34 | 8.6% | 21.3% | 13.8% |
| Age 35 to 44 | 12.2% | 14.5% | 12.9% |
| Age 45 to 54 | 15.3% | 11.2% | 12.6% |
| Age 55 to 59 | 9.6% | 6.9% | 6.7% |
| Age 60 to 64 | 8.2% | 5.7% | 6.3% |
| Age 65 to 74 | 9.9% | 9.1% | 9.6% |
| Age 75 to 84 | 5.2% | 4.0% | 4.5% |
| Age 85 and over | 1.1% | 2.2% | 1.9% |
| space1 | | | |
| Race | | | |
| | Holliston, MA | Portland, ME | United States |
| White | 87.0% | 81.7% | 59.4% |
| Black | 0.6% | 8.9% | 12.2% |
| Asian | 6.7% | 4.0% | 5.6% |
| Native American | 0.0% | 0.1% | 0.6% |
| Hawaiian, Pacific Islander | 0.0% | 0.0% | 0.2% |
| Other | 0.8% | 0.1% | 0.4% |
| Two or More Races | 1.7% | 2.8% | 3.2% |
| Hispanic | 3.1% | 2.4% | 18.4% |
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| Marriage & Family | | | |
| | Holliston, MA | Portland, ME | United States |
| Married Population | 63.0% | 39.6% | 49.8% |
| Currently Married | 62.2% | 38.6% | 48.0% |
| Married but Separated | 0.8% | 1.0% | 1.8% |
| Single Population | 37.0% | 60.4% | 50.2% |
| Never Married | 23.7% | 44.4% | 33.8% |
| Divorced | 7.5% | 11.4% | 10.8% |
| Widowed | 5.8% | 4.6% | 5.6% |
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| Household Size | 2.70 | 2.12 | 2.60 |
| Households | 5,485 | 31,237 | 124,010,992 |
| Family Households | 4,322 | 13,490 | 80,755,759 |
| Married couple, w/children | 38.1% | 28.1% | 30.5% |
| Married couple, no children | 47.0% | 49.2% | 42.9% |
| Non Family Households | 1,163 | 17,747 | 43,255,233 |
| Single householder, w/children | 4.4% | 13.7% | 15.8% |
| Single householder, no children | 10.6% | 9.0% | 10.8% |