| | Holly Springs, MS | De Queen, AR | United States |
| Population | 6,743 | 6,192 | 329,725,481 |
| Female Population | 47.1% | 54.4% | 50.5% |
| Male Population | 52.9% | 45.6% | 49.5% |
| Median Age | 39.4 | 31.9 | 38.4 |
| space3 | | | |
| Population - 2010 | 7,791 | 6,606 | 309,327,143 |
| Population - 2000 | 7,957 | 5,765 | 285,036,114 |
| Population - 1990 | 7,261 | 4,633 | 251,960,433 |
| Pop. 2000 to Now | -3.4% | 11.1% | 15.6% |
| Pop. 1990 to Now | 5.8% | 38.3% | 30.8% |
| space4 | | | |
| Population Density | 527.8 | 1,031.7 | 93.4 |
| Land Area | 12.8 | 6.0 | 3,531,905.4 |
| Water Area | 0.0 | 0.1 | 264,836.8 |
| space | | | |
| Est. Total Population By Age | | | |
| | Holly Springs, MS | De Queen, AR | United States |
| Age 0 to 4 | 4.0% | 8.2% | 5.9% |
| Age 5 to 9 | 4.4% | 8.3% | 6.1% |
| Age 10 to 14 | 3.9% | 9.9% | 6.6% |
| Age 15 to 17 | 2.8% | 5.9% | 3.9% |
| Age 18 to 20 | 8.7% | 4.6% | 4.0% |
| Age 21 to 24 | 5.1% | 5.4% | 5.2% |
| Age 25 to 34 | 16.4% | 9.7% | 13.8% |
| Age 35 to 44 | 15.7% | 15.7% | 12.9% |
| Age 45 to 54 | 12.0% | 12.6% | 12.6% |
| Age 55 to 59 | 9.3% | 5.5% | 6.7% |
| Age 60 to 64 | 6.2% | 4.4% | 6.3% |
| Age 65 to 74 | 6.7% | 4.7% | 9.6% |
| Age 75 to 84 | 2.6% | 4.5% | 4.5% |
| Age 85 and over | 2.2% | 0.5% | 1.9% |
| space1 | | | |
| Race | | | |
| | Holly Springs, MS | De Queen, AR | United States |
| White | 18.5% | 29.4% | 59.4% |
| Black | 78.5% | 3.3% | 12.2% |
| Asian | 0.0% | 0.0% | 5.6% |
| Native American | 0.1% | 1.1% | 0.6% |
| Hawaiian, Pacific Islander | 0.0% | 8.7% | 0.2% |
| Other | 0.0% | 0.0% | 0.4% |
| Two or More Races | 2.8% | 1.1% | 3.2% |
| Hispanic | 0.3% | 56.5% | 18.4% |
| space2 | | | |
| Marriage & Family | | | |
| | Holly Springs, MS | De Queen, AR | United States |
| Married Population | 28.5% | 42.7% | 49.8% |
| Currently Married | 25.9% | 42.3% | 48.0% |
| Married but Separated | 2.6% | 0.5% | 1.8% |
| Single Population | 71.5% | 57.3% | 50.2% |
| Never Married | 52.8% | 37.1% | 33.8% |
| Divorced | 12.2% | 14.1% | 10.8% |
| Widowed | 6.5% | 6.1% | 5.6% |
| space5 | | | |
| Household Size | 2.20 | 3.03 | 2.60 |
| Households | 2,192 | 2,015 | 124,010,992 |
| Family Households | 1,395 | 1,302 | 80,755,759 |
| Married couple, w/children | 7.3% | 49.5% | 30.5% |
| Married couple, no children | 30.8% | 22.3% | 42.9% |
| Non Family Households | 797 | 713 | 43,255,233 |
| Single householder, w/children | 33.8% | 12.0% | 15.8% |
| Single householder, no children | 28.0% | 16.3% | 10.8% |