| | Isle of Palms, SC | Destin, FL | United States |
| Population | 4,318 | 13,751 | 329,725,481 |
| Female Population | 51.2% | 48.8% | 50.5% |
| Male Population | 48.8% | 51.2% | 49.5% |
| Median Age | 51.7 | 43.3 | 38.4 |
| space3 | | | |
| Population - 2010 | 4,138 | 12,159 | 309,327,143 |
| Population - 2000 | 4,583 | 11,119 | 285,036,114 |
| Population - 1990 | 3,680 | 8,080 | 251,960,433 |
| Pop. 2000 to Now | -4.6% | 28.5% | 15.6% |
| Pop. 1990 to Now | 18.8% | 76.8% | 30.8% |
| space4 | | | |
| Population Density | 973.4 | 1,788.4 | 93.4 |
| Land Area | 4.4 | 7.7 | 3,531,905.4 |
| Water Area | 1.0 | 0.8 | 264,836.8 |
| space | | | |
| Est. Total Population By Age | | | |
| | Isle of Palms, SC | Destin, FL | United States |
| Age 0 to 4 | 2.9% | 4.3% | 5.9% |
| Age 5 to 9 | 7.3% | 6.0% | 6.1% |
| Age 10 to 14 | 5.2% | 3.3% | 6.6% |
| Age 15 to 17 | 2.2% | 3.2% | 3.9% |
| Age 18 to 20 | 0.8% | 2.6% | 4.0% |
| Age 21 to 24 | 2.2% | 3.2% | 5.2% |
| Age 25 to 34 | 3.9% | 13.4% | 13.8% |
| Age 35 to 44 | 12.6% | 15.7% | 12.9% |
| Age 45 to 54 | 16.7% | 13.9% | 12.6% |
| Age 55 to 59 | 7.8% | 8.0% | 6.7% |
| Age 60 to 64 | 10.2% | 8.3% | 6.3% |
| Age 65 to 74 | 19.3% | 12.9% | 9.6% |
| Age 75 to 84 | 5.8% | 4.1% | 4.5% |
| Age 85 and over | 3.1% | 1.0% | 1.9% |
| space1 | | | |
| Race | | | |
| | Isle of Palms, SC | Destin, FL | United States |
| White | 96.2% | 81.2% | 59.4% |
| Black | 0.0% | 2.5% | 12.2% |
| Asian | 2.0% | 1.1% | 5.6% |
| Native American | 0.0% | 0.1% | 0.6% |
| Hawaiian, Pacific Islander | 0.0% | 0.0% | 0.2% |
| Other | 0.0% | 0.4% | 0.4% |
| Two or More Races | 0.5% | 6.8% | 3.2% |
| Hispanic | 1.3% | 7.8% | 18.4% |
| space2 | | | |
| Marriage & Family | | | |
| | Isle of Palms, SC | Destin, FL | United States |
| Married Population | 72.6% | 51.8% | 49.8% |
| Currently Married | 72.2% | 48.8% | 48.0% |
| Married but Separated | 0.4% | 3.0% | 1.8% |
| Single Population | 27.4% | 48.2% | 50.2% |
| Never Married | 13.4% | 30.8% | 33.8% |
| Divorced | 10.8% | 13.6% | 10.8% |
| Widowed | 3.2% | 3.8% | 5.6% |
| space5 | | | |
| Household Size | 2.27 | 2.19 | 2.60 |
| Households | 1,903 | 6,201 | 124,010,992 |
| Family Households | 1,340 | 3,482 | 80,755,759 |
| Married couple, w/children | 24.0% | 25.4% | 30.5% |
| Married couple, no children | 69.3% | 55.2% | 42.9% |
| Non Family Households | 563 | 2,719 | 43,255,233 |
| Single householder, w/children | 3.5% | 11.5% | 15.8% |
| Single householder, no children | 3.2% | 8.0% | 10.8% |