| | Knoxville, IA | Kirksville, MO | United States |
| Population | 7,537 | 17,600 | 329,725,481 |
| Female Population | 53.6% | 52.5% | 50.5% |
| Male Population | 46.4% | 47.5% | 49.5% |
| Median Age | 40.1 | 23.6 | 38.4 |
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| Population - 2010 | 7,290 | 17,521 | 309,327,143 |
| Population - 2000 | 7,731 | 16,988 | 285,036,114 |
| Population - 1990 | 8,232 | 17,152 | 251,960,433 |
| Pop. 2000 to Now | -8.4% | 3.9% | 15.6% |
| Pop. 1990 to Now | -14.0% | 2.9% | 30.8% |
| space4 | | | |
| Population Density | 1,628.9 | 1,223.4 | 93.4 |
| Land Area | 4.6 | 14.4 | 3,531,905.4 |
| Water Area | 0.0 | 0.0 | 264,836.8 |
| space | | | |
| Est. Total Population By Age | | | |
| | Knoxville, IA | Kirksville, MO | United States |
| Age 0 to 4 | 5.9% | 4.3% | 5.9% |
| Age 5 to 9 | 4.5% | 4.7% | 6.1% |
| Age 10 to 14 | 5.4% | 5.1% | 6.6% |
| Age 15 to 17 | 4.1% | 2.6% | 3.9% |
| Age 18 to 20 | 2.6% | 18.9% | 4.0% |
| Age 21 to 24 | 8.1% | 16.7% | 5.2% |
| Age 25 to 34 | 14.8% | 10.1% | 13.8% |
| Age 35 to 44 | 9.7% | 8.3% | 12.9% |
| Age 45 to 54 | 9.6% | 8.0% | 12.6% |
| Age 55 to 59 | 7.0% | 5.2% | 6.7% |
| Age 60 to 64 | 7.0% | 3.6% | 6.3% |
| Age 65 to 74 | 10.1% | 6.6% | 9.6% |
| Age 75 to 84 | 5.3% | 3.6% | 4.5% |
| Age 85 and over | 5.9% | 2.2% | 1.9% |
| space1 | | | |
| Race | | | |
| | Knoxville, IA | Kirksville, MO | United States |
| White | 95.5% | 86.3% | 59.4% |
| Black | 0.4% | 5.6% | 12.2% |
| Asian | 0.9% | 2.9% | 5.6% |
| Native American | 0.0% | 0.2% | 0.6% |
| Hawaiian, Pacific Islander | 0.1% | 0.0% | 0.2% |
| Other | 0.0% | 0.0% | 0.4% |
| Two or More Races | 1.0% | 2.3% | 3.2% |
| Hispanic | 2.1% | 2.7% | 18.4% |
| space2 | | | |
| Marriage & Family | | | |
| | Knoxville, IA | Kirksville, MO | United States |
| Married Population | 52.4% | 32.2% | 49.8% |
| Currently Married | 51.8% | 30.5% | 48.0% |
| Married but Separated | 0.6% | 1.7% | 1.8% |
| Single Population | 47.6% | 67.8% | 50.2% |
| Never Married | 24.9% | 53.5% | 33.8% |
| Divorced | 14.8% | 8.8% | 10.8% |
| Widowed | 7.8% | 5.5% | 5.6% |
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| Household Size | 2.16 | 2.51 | 2.60 |
| Households | 3,406 | 6,020 | 124,010,992 |
| Family Households | 2,011 | 2,754 | 80,755,759 |
| Married couple, w/children | 35.6% | 31.6% | 30.5% |
| Married couple, no children | 42.1% | 46.8% | 42.9% |
| Non Family Households | 1,395 | 3,266 | 43,255,233 |
| Single householder, w/children | 16.0% | 13.4% | 15.8% |
| Single householder, no children | 6.4% | 8.2% | 10.8% |