| | Lawrence, IN | Madison, IN | United States |
| Population | 49,048 | 12,227 | 329,725,481 |
| Female Population | 52.0% | 56.6% | 50.5% |
| Male Population | 48.0% | 43.4% | 49.5% |
| Median Age | 34.2 | 43.9 | 38.4 |
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| Population - 2010 | 45,983 | 11,966 | 309,327,143 |
| Population - 2000 | 38,915 | 12,004 | 285,036,114 |
| Population - 1990 | 26,763 | 12,006 | 251,960,433 |
| Pop. 2000 to Now | 27.3% | -2.1% | 15.6% |
| Pop. 1990 to Now | 85.1% | -2.1% | 30.8% |
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| Population Density | 2,434.9 | 1,424.1 | 93.4 |
| Land Area | 20.1 | 8.6 | 3,531,905.4 |
| Water Area | 0.1 | 0.3 | 264,836.8 |
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| Est. Total Population By Age | | | |
| | Lawrence, IN | Madison, IN | United States |
| Age 0 to 4 | 7.3% | 4.8% | 5.9% |
| Age 5 to 9 | 6.8% | 4.3% | 6.1% |
| Age 10 to 14 | 8.3% | 4.6% | 6.6% |
| Age 15 to 17 | 3.8% | 3.4% | 3.9% |
| Age 18 to 20 | 2.8% | 4.2% | 4.0% |
| Age 21 to 24 | 5.7% | 4.1% | 5.2% |
| Age 25 to 34 | 16.4% | 12.2% | 13.8% |
| Age 35 to 44 | 14.4% | 14.0% | 12.9% |
| Age 45 to 54 | 10.7% | 15.3% | 12.6% |
| Age 55 to 59 | 6.1% | 8.2% | 6.7% |
| Age 60 to 64 | 6.3% | 6.5% | 6.3% |
| Age 65 to 74 | 7.6% | 10.4% | 9.6% |
| Age 75 to 84 | 2.6% | 5.6% | 4.5% |
| Age 85 and over | 1.2% | 2.4% | 1.9% |
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| Race | | | |
| | Lawrence, IN | Madison, IN | United States |
| White | 51.1% | 87.7% | 59.4% |
| Black | 25.9% | 3.9% | 12.2% |
| Asian | 1.7% | 1.2% | 5.6% |
| Native American | 0.2% | 0.1% | 0.6% |
| Hawaiian, Pacific Islander | 0.2% | 0.0% | 0.2% |
| Other | 0.6% | 1.1% | 0.4% |
| Two or More Races | 4.0% | 1.9% | 3.2% |
| Hispanic | 16.4% | 4.0% | 18.4% |
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| Marriage & Family | | | |
| | Lawrence, IN | Madison, IN | United States |
| Married Population | 47.2% | 39.4% | 49.8% |
| Currently Married | 46.5% | 37.2% | 48.0% |
| Married but Separated | 0.8% | 2.2% | 1.8% |
| Single Population | 52.8% | 60.6% | 50.2% |
| Never Married | 38.2% | 31.0% | 33.8% |
| Divorced | 9.7% | 21.5% | 10.8% |
| Widowed | 4.9% | 8.0% | 5.6% |
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| Household Size | 2.59 | 2.18 | 2.60 |
| Households | 18,891 | 5,064 | 124,010,992 |
| Family Households | 11,483 | 2,650 | 80,755,759 |
| Married couple, w/children | 32.9% | 32.1% | 30.5% |
| Married couple, no children | 39.9% | 38.3% | 42.9% |
| Non Family Households | 7,408 | 2,414 | 43,255,233 |
| Single householder, w/children | 18.8% | 18.9% | 15.8% |
| Single householder, no children | 8.4% | 10.6% | 10.8% |