| | Melissa, TX | Anna, TX | United States |
| Population | 13,671 | 16,792 | 329,725,481 |
| Female Population | 54.4% | 51.9% | 50.5% |
| Male Population | 45.6% | 48.1% | 49.5% |
| Median Age | 36.5 | 31.2 | 38.4 |
| space3 | | | |
| Population - 2010 | 4,844 | 8,279 | 309,327,143 |
| Population - 2000 | 1,350 | 1,225 | 285,036,114 |
| Population - 1990 | 557 | 904 | 251,960,433 |
| Pop. 2000 to Now | 921.7% | 1,283.3% | 15.6% |
| Pop. 1990 to Now | 2,376.3% | 1,774.5% | 30.8% |
| space4 | | | |
| Population Density | 1,194.2 | 1,046.4 | 93.4 |
| Land Area | 11.4 | 16.0 | 3,531,905.4 |
| Water Area | 0.1 | 0.1 | 264,836.8 |
| space | | | |
| Est. Total Population By Age | | | |
| | Melissa, TX | Anna, TX | United States |
| Age 0 to 4 | 8.0% | 10.7% | 5.9% |
| Age 5 to 9 | 6.9% | 8.3% | 6.1% |
| Age 10 to 14 | 9.8% | 8.7% | 6.6% |
| Age 15 to 17 | 5.9% | 4.8% | 3.9% |
| Age 18 to 20 | 5.8% | 0.6% | 4.0% |
| Age 21 to 24 | 3.0% | 6.0% | 5.2% |
| Age 25 to 34 | 8.9% | 21.5% | 13.8% |
| Age 35 to 44 | 21.2% | 17.5% | 12.9% |
| Age 45 to 54 | 15.8% | 9.5% | 12.6% |
| Age 55 to 59 | 3.5% | 3.3% | 6.7% |
| Age 60 to 64 | 3.0% | 3.8% | 6.3% |
| Age 65 to 74 | 5.4% | 3.3% | 9.6% |
| Age 75 to 84 | 1.3% | 2.0% | 4.5% |
| Age 85 and over | 1.7% | 0.0% | 1.9% |
| space1 | | | |
| Race | | | |
| | Melissa, TX | Anna, TX | United States |
| White | 69.9% | 58.7% | 59.4% |
| Black | 10.0% | 15.0% | 12.2% |
| Asian | 5.2% | 2.4% | 5.6% |
| Native American | 0.0% | 0.6% | 0.6% |
| Hawaiian, Pacific Islander | 0.0% | 0.0% | 0.2% |
| Other | 0.1% | 0.0% | 0.4% |
| Two or More Races | 3.4% | 2.5% | 3.2% |
| Hispanic | 11.3% | 20.7% | 18.4% |
| space2 | | | |
| Marriage & Family | | | |
| | Melissa, TX | Anna, TX | United States |
| Married Population | 65.8% | 61.0% | 49.8% |
| Currently Married | 65.8% | 60.7% | 48.0% |
| Married but Separated | 0.0% | 0.3% | 1.8% |
| Single Population | 34.2% | 39.0% | 50.2% |
| Never Married | 27.5% | 25.7% | 33.8% |
| Divorced | 2.7% | 10.3% | 10.8% |
| Widowed | 4.0% | 3.0% | 5.6% |
| space5 | | | |
| Household Size | 3.28 | 3.06 | 2.60 |
| Households | 4,164 | 5,488 | 124,010,992 |
| Family Households | 3,733 | 4,436 | 80,755,759 |
| Married couple, w/children | 52.5% | 48.7% | 30.5% |
| Married couple, no children | 30.8% | 30.8% | 42.9% |
| Non Family Households | 431 | 1,052 | 43,255,233 |
| Single householder, w/children | 12.7% | 15.8% | 15.8% |
| Single householder, no children | 4.0% | 4.7% | 10.8% |