| | St. James, MN | Comfrey, MN | United States |
| Population | 4,749 | 305 | 329,725,481 |
| Female Population | 46.1% | 51.5% | 50.5% |
| Male Population | 53.9% | 48.5% | 49.5% |
| Median Age | 38 | 47.3 | 38.4 |
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| Population - 2010 | 4,589 | 383 | 309,327,143 |
| Population - 2000 | 4,695 | 367 | 285,036,114 |
| Population - 1990 | 4,364 | 433 | 251,960,433 |
| Pop. 2000 to Now | -7.2% | -4.1% | 15.6% |
| Pop. 1990 to Now | -0.1% | -18.7% | 30.8% |
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| Population Density | 2,039.1 | 712.6 | 93.4 |
| Land Area | 2.3 | 0.4 | 3,531,905.4 |
| Water Area | 0.0 | 0.0 | 264,836.8 |
| space | | | |
| Est. Total Population By Age | | | |
| | St. James, MN | Comfrey, MN | United States |
| Age 0 to 4 | 5.5% | 3.9% | 5.9% |
| Age 5 to 9 | 8.3% | 6.2% | 6.1% |
| Age 10 to 14 | 8.7% | 8.5% | 6.6% |
| Age 15 to 17 | 4.7% | 1.6% | 3.9% |
| Age 18 to 20 | 4.4% | 0.7% | 4.0% |
| Age 21 to 24 | 3.3% | 4.6% | 5.2% |
| Age 25 to 34 | 11.3% | 7.2% | 13.8% |
| Age 35 to 44 | 12.1% | 15.4% | 12.9% |
| Age 45 to 54 | 10.2% | 9.5% | 12.6% |
| Age 55 to 59 | 7.3% | 8.9% | 6.7% |
| Age 60 to 64 | 8.2% | 4.9% | 6.3% |
| Age 65 to 74 | 6.6% | 14.8% | 9.6% |
| Age 75 to 84 | 4.4% | 9.2% | 4.5% |
| Age 85 and over | 5.2% | 4.6% | 1.9% |
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| Race | | | |
| | St. James, MN | Comfrey, MN | United States |
| White | 56.2% | 94.8% | 59.4% |
| Black | 0.1% | 0.0% | 12.2% |
| Asian | 0.0% | 0.7% | 5.6% |
| Native American | 0.0% | 0.0% | 0.6% |
| Hawaiian, Pacific Islander | 0.0% | 0.0% | 0.2% |
| Other | 0.3% | 0.0% | 0.4% |
| Two or More Races | 0.8% | 2.0% | 3.2% |
| Hispanic | 42.6% | 2.6% | 18.4% |
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| Marriage & Family | | | |
| | St. James, MN | Comfrey, MN | United States |
| Married Population | 55.7% | 52.4% | 49.8% |
| Currently Married | 52.4% | 51.2% | 48.0% |
| Married but Separated | 3.3% | 1.2% | 1.8% |
| Single Population | 44.3% | 47.6% | 50.2% |
| Never Married | 28.0% | 21.4% | 33.8% |
| Divorced | 7.0% | 10.5% | 10.8% |
| Widowed | 9.2% | 15.7% | 5.6% |
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| Household Size | 2.48 | 1.89 | 2.60 |
| Households | 1,890 | 161 | 124,010,992 |
| Family Households | 1,144 | 74 | 80,755,759 |
| Married couple, w/children | 37.9% | 24.3% | 30.5% |
| Married couple, no children | 42.7% | 60.8% | 42.9% |
| Non Family Households | 746 | 87 | 43,255,233 |
| Single householder, w/children | 10.3% | 8.1% | 15.8% |
| Single householder, no children | 9.0% | 6.8% | 10.8% |