| | Tanana, AK | Manley Hot Springs, AK | United States |
| Population | 190 | 35 | 329,725,481 |
| Female Population | 42.6% | 62.9% | 50.5% |
| Male Population | 57.4% | 37.1% | 49.5% |
| Median Age | 42 | 50.3 | 38.4 |
| space3 | | | |
| Population - 2010 | 247 | 75 | 309,327,143 |
| Population - 2000 | 308 | 72 | 285,036,114 |
| Population - 1990 | 345 | 96 | 251,960,433 |
| Pop. 2000 to Now | -22.1% | 0.0% | 15.6% |
| Pop. 1990 to Now | -30.4% | -25.0% | 30.8% |
| space4 | | | |
| Population Density | 17.8 | 0.6 | 93.4 |
| Land Area | 10.7 | 54.6 | 3,531,905.4 |
| Water Area | 4.3 | 0.0 | 264,836.8 |
| space | | | |
| Est. Total Population By Age | | | |
| | Tanana, AK | Manley Hot Springs, AK | United States |
| Age 0 to 4 | 10.0% | 0.0% | 5.9% |
| Age 5 to 9 | 11.6% | 11.4% | 6.1% |
| Age 10 to 14 | 4.2% | 0.0% | 6.6% |
| Age 15 to 17 | 0.5% | 5.7% | 3.9% |
| Age 18 to 20 | 1.6% | 0.0% | 4.0% |
| Age 21 to 24 | 5.8% | 0.0% | 5.2% |
| Age 25 to 34 | 10.5% | 8.6% | 13.8% |
| Age 35 to 44 | 8.9% | 22.9% | 12.9% |
| Age 45 to 54 | 11.6% | 25.7% | 12.6% |
| Age 55 to 59 | 5.8% | 14.3% | 6.7% |
| Age 60 to 64 | 7.4% | 11.4% | 6.3% |
| Age 65 to 74 | 15.3% | 0.0% | 9.6% |
| Age 75 to 84 | 4.7% | 0.0% | 4.5% |
| Age 85 and over | 2.1% | 0.0% | 1.9% |
| space1 | | | |
| Race | | | |
| | Tanana, AK | Manley Hot Springs, AK | United States |
| White | 13.2% | 62.9% | 59.4% |
| Black | 0.0% | 0.0% | 12.2% |
| Asian | 0.0% | 0.0% | 5.6% |
| Native American | 82.1% | 5.7% | 0.6% |
| Hawaiian, Pacific Islander | 0.0% | 0.0% | 0.2% |
| Other | 0.0% | 0.0% | 0.4% |
| Two or More Races | 4.7% | 31.4% | 3.2% |
| Hispanic | 0.0% | 0.0% | 18.4% |
| space2 | | | |
| Marriage & Family | | | |
| | Tanana, AK | Manley Hot Springs, AK | United States |
| Married Population | 38.3% | 77.4% | 49.8% |
| Currently Married | 38.3% | 77.4% | 48.0% |
| Married but Separated | 0.0% | 0.0% | 1.8% |
| Single Population | 61.7% | 22.6% | 50.2% |
| Never Married | 45.4% | 19.4% | 33.8% |
| Divorced | 7.8% | 0.0% | 10.8% |
| Widowed | 8.5% | 3.2% | 5.6% |
| space5 | | | |
| Household Size | 2.57 | 1.84 | 2.60 |
| Households | 70 | 19 | 124,010,992 |
| Family Households | 41 | 12 | 80,755,759 |
| Married couple, w/children | 41.5% | 25.0% | 30.5% |
| Married couple, no children | 14.6% | 75.0% | 42.9% |
| Non Family Households | 29 | 7 | 43,255,233 |
| Single householder, w/children | 26.8% | 0.0% | 15.8% |
| Single householder, no children | 17.1% | 0.0% | 10.8% |