South San Francisco, CA is 94128 zip code area and it offers many public transportation options to its residents. The most popular of these include the SamTrans bus service, which connects South San Francisco and the Bay Area. Additionally, there is a Caltrain Station located in South San Francisco that offers daily frequent service to destinations throughout California. For those who would prefer to travel by car, two major highways, US 101 and Interstate 280 provide easy access from South San Francisco to nearby cities such as San Jose, Palo Alto and even further afield. If you're looking for a green option, there are several bike share programs in place that allow riders an affordable way to get around town. Finally, if you're travelling outside of the city limits, Greyhound provides reliable bus services across the entire country at reasonable rates. With all these transportation options available in South San Francisco, getting around has never been easier!