| | Depoe Bay, OR | Sisters, OR | United States |
| Population | 2,140 | 2,945 | 329,725,481 |
| Female Population | 55.4% | 53.5% | 50.5% |
| Male Population | 44.6% | 46.5% | 49.5% |
| Median Age | 56 | 48.5 | 38.4 |
| space3 | | | |
| Population - 2010 | 1,374 | 2,040 | 309,327,143 |
| Population - 2000 | 1,174 | 959 | 285,036,114 |
| Population - 1990 | 870 | 679 | 251,960,433 |
| Pop. 2000 to Now | 27.2% | 193.1% | 15.6% |
| Pop. 1990 to Now | 71.6% | 314.0% | 30.8% |
| space4 | | | |
| Population Density | 1,181.7 | 1,568.2 | 93.4 |
| Land Area | 1.8 | 1.9 | 3,531,905.4 |
| Water Area | 0.0 | 0.0 | 264,836.8 |
| space | | | |
| Est. Total Population By Age | | | |
| | Depoe Bay, OR | Sisters, OR | United States |
| Age 0 to 4 | 3.5% | 5.6% | 5.9% |
| Age 5 to 9 | 5.0% | 3.7% | 6.1% |
| Age 10 to 14 | 0.9% | 3.7% | 6.6% |
| Age 15 to 17 | 0.4% | 4.5% | 3.9% |
| Age 18 to 20 | 0.0% | 3.1% | 4.0% |
| Age 21 to 24 | 1.6% | 2.9% | 5.2% |
| Age 25 to 34 | 11.7% | 9.7% | 13.8% |
| Age 35 to 44 | 14.7% | 11.3% | 12.9% |
| Age 45 to 54 | 9.0% | 12.7% | 12.6% |
| Age 55 to 59 | 8.5% | 3.7% | 6.7% |
| Age 60 to 64 | 12.2% | 5.2% | 6.3% |
| Age 65 to 74 | 24.3% | 29.3% | 9.6% |
| Age 75 to 84 | 6.5% | 2.9% | 4.5% |
| Age 85 and over | 1.7% | 1.6% | 1.9% |
| space1 | | | |
| Race | | | |
| | Depoe Bay, OR | Sisters, OR | United States |
| White | 94.0% | 91.5% | 59.4% |
| Black | 0.0% | 0.0% | 12.2% |
| Asian | 1.0% | 0.0% | 5.6% |
| Native American | 0.0% | 0.5% | 0.6% |
| Hawaiian, Pacific Islander | 0.0% | 0.0% | 0.2% |
| Other | 0.0% | 1.0% | 0.4% |
| Two or More Races | 1.6% | 1.7% | 3.2% |
| Hispanic | 3.4% | 5.3% | 18.4% |
| space2 | | | |
| Marriage & Family | | | |
| | Depoe Bay, OR | Sisters, OR | United States |
| Married Population | 62.1% | 69.4% | 49.8% |
| Currently Married | 62.1% | 68.9% | 48.0% |
| Married but Separated | 0.0% | 0.5% | 1.8% |
| Single Population | 37.9% | 30.6% | 50.2% |
| Never Married | 18.4% | 16.8% | 33.8% |
| Divorced | 13.0% | 10.3% | 10.8% |
| Widowed | 6.4% | 3.6% | 5.6% |
| space5 | | | |
| Household Size | 1.94 | 2.24 | 2.60 |
| Households | 1,105 | 1,299 | 124,010,992 |
| Family Households | 642 | 954 | 80,755,759 |
| Married couple, w/children | 19.9% | 33.2% | 30.5% |
| Married couple, no children | 62.8% | 61.4% | 42.9% |
| Non Family Households | 463 | 345 | 43,255,233 |
| Single householder, w/children | 6.1% | 2.2% | 15.8% |
| Single householder, no children | 11.2% | 3.1% | 10.8% |