| | Manitowoc, WI | La Crosse, WI | United States |
| Population | 34,267 | 52,505 | 329,725,481 |
| Female Population | 50.2% | 51.6% | 50.5% |
| Male Population | 49.9% | 48.4% | 49.5% |
| Median Age | 43.4 | 29.4 | 38.4 |
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| Population - 2010 | 33,646 | 51,373 | 309,327,143 |
| Population - 2000 | 34,053 | 51,818 | 285,036,114 |
| Population - 1990 | 32,520 | 51,003 | 251,960,433 |
| Pop. 2000 to Now | -5.0% | -1.3% | 15.6% |
| Pop. 1990 to Now | -0.5% | 0.3% | 30.8% |
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| Population Density | 1,927.3 | 2,416.7 | 93.4 |
| Land Area | 17.8 | 21.7 | 3,531,905.4 |
| Water Area | 0.4 | 2.1 | 264,836.8 |
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| Est. Total Population By Age | | | |
| | Manitowoc, WI | La Crosse, WI | United States |
| Age 0 to 4 | 5.1% | 4.6% | 5.9% |
| Age 5 to 9 | 5.1% | 3.6% | 6.1% |
| Age 10 to 14 | 6.8% | 4.7% | 6.6% |
| Age 15 to 17 | 4.0% | 2.2% | 3.9% |
| Age 18 to 20 | 3.0% | 14.0% | 4.0% |
| Age 21 to 24 | 4.6% | 13.3% | 5.2% |
| Age 25 to 34 | 12.0% | 15.0% | 13.8% |
| Age 35 to 44 | 10.9% | 9.8% | 12.9% |
| Age 45 to 54 | 12.4% | 8.0% | 12.6% |
| Age 55 to 59 | 7.6% | 5.0% | 6.7% |
| Age 60 to 64 | 7.6% | 4.8% | 6.3% |
| Age 65 to 74 | 12.2% | 8.1% | 9.6% |
| Age 75 to 84 | 5.7% | 4.0% | 4.5% |
| Age 85 and over | 3.1% | 2.9% | 1.9% |
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| Race | | | |
| | Manitowoc, WI | La Crosse, WI | United States |
| White | 84.3% | 88.4% | 59.4% |
| Black | 2.1% | 2.2% | 12.2% |
| Asian | 5.5% | 4.1% | 5.6% |
| Native American | 0.4% | 0.3% | 0.6% |
| Hawaiian, Pacific Islander | 0.0% | 0.0% | 0.2% |
| Other | 0.1% | 0.1% | 0.4% |
| Two or More Races | 2.1% | 2.5% | 3.2% |
| Hispanic | 5.6% | 2.4% | 18.4% |
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| Marriage & Family | | | |
| | Manitowoc, WI | La Crosse, WI | United States |
| Married Population | 46.4% | 29.4% | 49.8% |
| Currently Married | 45.0% | 28.5% | 48.0% |
| Married but Separated | 1.4% | 0.9% | 1.8% |
| Single Population | 53.6% | 70.6% | 50.2% |
| Never Married | 31.3% | 54.1% | 33.8% |
| Divorced | 14.1% | 10.7% | 10.8% |
| Widowed | 8.2% | 5.7% | 5.6% |
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| Household Size | 2.24 | 2.17 | 2.60 |
| Households | 14,874 | 22,117 | 124,010,992 |
| Family Households | 8,404 | 9,475 | 80,755,759 |
| Married couple, w/children | 24.8% | 27.1% | 30.5% |
| Married couple, no children | 45.4% | 38.8% | 42.9% |
| Non Family Households | 6,470 | 12,642 | 43,255,233 |
| Single householder, w/children | 21.0% | 19.5% | 15.8% |
| Single householder, no children | 8.8% | 14.6% | 10.8% |