| | Medicine Park, OK | Tishomingo, OK | United States |
| Population | 302 | 2,978 | 329,725,481 |
| Female Population | 52.7% | 50.8% | 50.5% |
| Male Population | 47.4% | 49.2% | 49.5% |
| Median Age | 47.8 | 30.3 | 38.4 |
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| Population - 2010 | 388 | 3,049 | 309,327,143 |
| Population - 2000 | 373 | 3,162 | 285,036,114 |
| Population - 1990 | 285 | 3,116 | 251,960,433 |
| Pop. 2000 to Now | 23.6% | -5.2% | 15.6% |
| Pop. 1990 to Now | 61.8% | -3.8% | 30.8% |
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| Population Density | 149.9 | 682.6 | 93.4 |
| Land Area | 2.0 | 4.4 | 3,531,905.4 |
| Water Area | 0.1 | 0.1 | 264,836.8 |
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| Est. Total Population By Age | | | |
| | Medicine Park, OK | Tishomingo, OK | United States |
| Age 0 to 4 | 1.0% | 8.0% | 5.9% |
| Age 5 to 9 | 10.6% | 5.6% | 6.1% |
| Age 10 to 14 | 2.3% | 8.8% | 6.6% |
| Age 15 to 17 | 2.6% | 4.1% | 3.9% |
| Age 18 to 20 | 0.0% | 8.8% | 4.0% |
| Age 21 to 24 | 2.3% | 7.7% | 5.2% |
| Age 25 to 34 | 7.6% | 11.0% | 13.8% |
| Age 35 to 44 | 12.3% | 9.4% | 12.9% |
| Age 45 to 54 | 31.1% | 10.0% | 12.6% |
| Age 55 to 59 | 3.3% | 6.6% | 6.7% |
| Age 60 to 64 | 13.6% | 5.1% | 6.3% |
| Age 65 to 74 | 7.9% | 7.0% | 9.6% |
| Age 75 to 84 | 5.3% | 6.4% | 4.5% |
| Age 85 and over | 0.0% | 1.6% | 1.9% |
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| Race | | | |
| | Medicine Park, OK | Tishomingo, OK | United States |
| White | 92.1% | 58.1% | 59.4% |
| Black | 1.0% | 2.8% | 12.2% |
| Asian | 0.0% | 0.0% | 5.6% |
| Native American | 2.6% | 13.0% | 0.6% |
| Hawaiian, Pacific Islander | 0.0% | 0.0% | 0.2% |
| Other | 0.0% | 0.0% | 0.4% |
| Two or More Races | 2.6% | 16.8% | 3.2% |
| Hispanic | 1.7% | 9.4% | 18.4% |
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| Marriage & Family | | | |
| | Medicine Park, OK | Tishomingo, OK | United States |
| Married Population | 61.9% | 29.3% | 49.8% |
| Currently Married | 60.0% | 26.6% | 48.0% |
| Married but Separated | 1.9% | 2.7% | 1.8% |
| Single Population | 38.1% | 70.7% | 50.2% |
| Never Married | 7.7% | 40.5% | 33.8% |
| Divorced | 23.5% | 24.0% | 10.8% |
| Widowed | 6.9% | 6.3% | 5.6% |
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| Household Size | 2.03 | 2.52 | 2.60 |
| Households | 149 | 1,070 | 124,010,992 |
| Family Households | 102 | 689 | 80,755,759 |
| Married couple, w/children | 15.7% | 6.2% | 30.5% |
| Married couple, no children | 72.5% | 34.4% | 42.9% |
| Non Family Households | 47 | 381 | 43,255,233 |
| Single householder, w/children | 6.9% | 38.9% | 15.8% |
| Single householder, no children | 4.9% | 20.5% | 10.8% |