| | Murphysboro, IL | Mattoon, IL | United States |
| Population | 7,270 | 16,982 | 329,725,481 |
| Female Population | 54.9% | 50.4% | 50.5% |
| Male Population | 45.1% | 49.6% | 49.5% |
| Median Age | 38.9 | 42.8 | 38.4 |
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| Population - 2010 | 7,981 | 18,553 | 309,327,143 |
| Population - 2000 | 13,295 | 18,291 | 285,036,114 |
| Population - 1990 | 9,176 | 18,441 | 251,960,433 |
| Pop. 2000 to Now | -44.5% | -4.3% | 15.6% |
| Pop. 1990 to Now | -19.5% | -5.0% | 30.8% |
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| Population Density | 1,402.9 | 1,647.8 | 93.4 |
| Land Area | 5.2 | 10.3 | 3,531,905.4 |
| Water Area | 0.1 | 0.0 | 264,836.8 |
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| Est. Total Population By Age | | | |
| | Murphysboro, IL | Mattoon, IL | United States |
| Age 0 to 4 | 8.6% | 4.7% | 5.9% |
| Age 5 to 9 | 6.6% | 5.5% | 6.1% |
| Age 10 to 14 | 7.3% | 7.6% | 6.6% |
| Age 15 to 17 | 2.8% | 3.1% | 3.9% |
| Age 18 to 20 | 2.9% | 4.0% | 4.0% |
| Age 21 to 24 | 4.1% | 5.1% | 5.2% |
| Age 25 to 34 | 11.6% | 11.7% | 13.8% |
| Age 35 to 44 | 13.9% | 13.0% | 12.9% |
| Age 45 to 54 | 9.7% | 12.8% | 12.6% |
| Age 55 to 59 | 6.9% | 7.3% | 6.7% |
| Age 60 to 64 | 6.1% | 6.2% | 6.3% |
| Age 65 to 74 | 9.7% | 10.1% | 9.6% |
| Age 75 to 84 | 6.2% | 5.5% | 4.5% |
| Age 85 and over | 3.8% | 3.4% | 1.9% |
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| Race | | | |
| | Murphysboro, IL | Mattoon, IL | United States |
| White | 71.7% | 92.9% | 59.4% |
| Black | 15.1% | 2.3% | 12.2% |
| Asian | 0.3% | 0.1% | 5.6% |
| Native American | 0.0% | 0.0% | 0.6% |
| Hawaiian, Pacific Islander | 0.0% | 0.0% | 0.2% |
| Other | 0.2% | 0.0% | 0.4% |
| Two or More Races | 4.1% | 2.0% | 3.2% |
| Hispanic | 8.6% | 2.7% | 18.4% |
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| Marriage & Family | | | |
| | Murphysboro, IL | Mattoon, IL | United States |
| Married Population | 42.4% | 39.3% | 49.8% |
| Currently Married | 39.6% | 38.5% | 48.0% |
| Married but Separated | 2.8% | 0.8% | 1.8% |
| Single Population | 57.6% | 60.7% | 50.2% |
| Never Married | 27.9% | 30.0% | 33.8% |
| Divorced | 21.3% | 21.3% | 10.8% |
| Widowed | 8.4% | 9.4% | 5.6% |
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| Household Size | 2.08 | 2.06 | 2.60 |
| Households | 3,380 | 8,012 | 124,010,992 |
| Family Households | 1,803 | 4,308 | 80,755,759 |
| Married couple, w/children | 21.5% | 20.8% | 30.5% |
| Married couple, no children | 35.5% | 39.3% | 42.9% |
| Non Family Households | 1,577 | 3,704 | 43,255,233 |
| Single householder, w/children | 28.2% | 26.4% | 15.8% |
| Single householder, no children | 14.9% | 13.4% | 10.8% |