| | Seneca, SC | Winston-Salem, NC | United States |
| Population | 8,734 | 247,917 | 329,725,481 |
| Female Population | 53.0% | 52.9% | 50.5% |
| Male Population | 47.0% | 47.1% | 49.5% |
| Median Age | 39.6 | 35.9 | 38.4 |
| space3 | | | |
| Population - 2010 | 8,111 | 230,024 | 309,327,143 |
| Population - 2000 | 7,652 | 185,776 | 285,036,114 |
| Population - 1990 | 7,726 | 143,485 | 251,960,433 |
| Pop. 2000 to Now | 11.9% | 33.6% | 15.6% |
| Pop. 1990 to Now | 10.9% | 72.9% | 30.8% |
| space4 | | | |
| Population Density | 1,110.5 | 1,870.3 | 93.4 |
| Land Area | 7.9 | 132.6 | 3,531,905.4 |
| Water Area | 0.1 | 1.2 | 264,836.8 |
| space | | | |
| Est. Total Population By Age | | | |
| | Seneca, SC | Winston-Salem, NC | United States |
| Age 0 to 4 | 8.3% | 6.0% | 5.9% |
| Age 5 to 9 | 3.7% | 6.0% | 6.1% |
| Age 10 to 14 | 4.5% | 7.0% | 6.6% |
| Age 15 to 17 | 2.5% | 4.3% | 3.9% |
| Age 18 to 20 | 3.9% | 5.9% | 4.0% |
| Age 21 to 24 | 1.8% | 5.2% | 5.2% |
| Age 25 to 34 | 19.6% | 14.4% | 13.8% |
| Age 35 to 44 | 11.4% | 12.2% | 12.9% |
| Age 45 to 54 | 9.3% | 12.3% | 12.6% |
| Age 55 to 59 | 6.6% | 6.4% | 6.7% |
| Age 60 to 64 | 8.4% | 6.0% | 6.3% |
| Age 65 to 74 | 10.6% | 8.5% | 9.6% |
| Age 75 to 84 | 7.1% | 4.0% | 4.5% |
| Age 85 and over | 2.3% | 1.7% | 1.9% |
| space1 | | | |
| Race | | | |
| | Seneca, SC | Winston-Salem, NC | United States |
| White | 69.3% | 45.0% | 59.4% |
| Black | 20.7% | 32.8% | 12.2% |
| Asian | 0.2% | 2.5% | 5.6% |
| Native American | 0.3% | 0.2% | 0.6% |
| Hawaiian, Pacific Islander | 0.0% | 0.1% | 0.2% |
| Other | 0.0% | 0.4% | 0.4% |
| Two or More Races | 1.6% | 2.9% | 3.2% |
| Hispanic | 7.8% | 16.2% | 18.4% |
| space2 | | | |
| Marriage & Family | | | |
| | Seneca, SC | Winston-Salem, NC | United States |
| Married Population | 45.0% | 41.7% | 49.8% |
| Currently Married | 41.8% | 39.1% | 48.0% |
| Married but Separated | 3.2% | 2.6% | 1.8% |
| Single Population | 55.0% | 58.3% | 50.2% |
| Never Married | 34.2% | 41.9% | 33.8% |
| Divorced | 13.2% | 11.0% | 10.8% |
| Widowed | 7.6% | 5.4% | 5.6% |
| space5 | | | |
| Household Size | 2.36 | 2.43 | 2.60 |
| Households | 3,678 | 97,869 | 124,010,992 |
| Family Households | 2,025 | 56,451 | 80,755,759 |
| Married couple, w/children | 21.3% | 26.2% | 30.5% |
| Married couple, no children | 51.6% | 38.6% | 42.9% |
| Non Family Households | 1,653 | 41,418 | 43,255,233 |
| Single householder, w/children | 16.4% | 23.1% | 15.8% |
| Single householder, no children | 10.7% | 12.1% | 10.8% |