| | Tuscaloosa, AL | Prattville, AL | United States |
| Population | 99,252 | 37,977 | 329,725,481 |
| Female Population | 52.0% | 51.5% | 50.5% |
| Male Population | 48.0% | 48.6% | 49.5% |
| Median Age | 29.5 | 37.3 | 38.4 |
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| Population - 2010 | 90,409 | 34,408 | 309,327,143 |
| Population - 2000 | 77,906 | 24,303 | 285,036,114 |
| Population - 1990 | 77,759 | 19,587 | 251,960,433 |
| Pop. 2000 to Now | 32.0% | 50.2% | 15.6% |
| Pop. 1990 to Now | 32.2% | 86.4% | 30.8% |
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| Population Density | 1,608.4 | 1,121.7 | 93.4 |
| Land Area | 61.7 | 33.9 | 3,531,905.4 |
| Water Area | 10.1 | 0.9 | 264,836.8 |
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| Est. Total Population By Age | | | |
| | Tuscaloosa, AL | Prattville, AL | United States |
| Age 0 to 4 | 5.5% | 5.7% | 5.9% |
| Age 5 to 9 | 5.2% | 6.5% | 6.1% |
| Age 10 to 14 | 4.7% | 6.6% | 6.6% |
| Age 15 to 17 | 2.8% | 4.8% | 3.9% |
| Age 18 to 20 | 13.6% | 3.0% | 4.0% |
| Age 21 to 24 | 10.9% | 6.6% | 5.2% |
| Age 25 to 34 | 14.7% | 13.8% | 13.8% |
| Age 35 to 44 | 10.8% | 13.1% | 12.9% |
| Age 45 to 54 | 8.9% | 13.7% | 12.6% |
| Age 55 to 59 | 4.7% | 7.0% | 6.7% |
| Age 60 to 64 | 5.1% | 4.9% | 6.3% |
| Age 65 to 74 | 8.0% | 9.0% | 9.6% |
| Age 75 to 84 | 3.8% | 3.6% | 4.5% |
| Age 85 and over | 1.2% | 1.8% | 1.9% |
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| Race | | | |
| | Tuscaloosa, AL | Prattville, AL | United States |
| White | 47.4% | 70.7% | 59.4% |
| Black | 44.0% | 20.9% | 12.2% |
| Asian | 2.6% | 1.9% | 5.6% |
| Native American | 0.1% | 0.2% | 0.6% |
| Hawaiian, Pacific Islander | 0.0% | 0.0% | 0.2% |
| Other | 0.1% | 0.2% | 0.4% |
| Two or More Races | 1.5% | 2.7% | 3.2% |
| Hispanic | 4.4% | 3.5% | 18.4% |
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| Marriage & Family | | | |
| | Tuscaloosa, AL | Prattville, AL | United States |
| Married Population | 34.3% | 51.1% | 49.8% |
| Currently Married | 32.6% | 49.2% | 48.0% |
| Married but Separated | 1.8% | 1.9% | 1.8% |
| Single Population | 65.7% | 48.9% | 50.2% |
| Never Married | 52.3% | 30.3% | 33.8% |
| Divorced | 9.4% | 13.1% | 10.8% |
| Widowed | 4.0% | 5.6% | 5.6% |
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| Household Size | 2.45 | 2.62 | 2.60 |
| Households | 36,763 | 14,301 | 124,010,992 |
| Family Households | 19,428 | 10,075 | 80,755,759 |
| Married couple, w/children | 25.2% | 32.4% | 30.5% |
| Married couple, no children | 39.5% | 39.6% | 42.9% |
| Non Family Households | 17,335 | 4,226 | 43,255,233 |
| Single householder, w/children | 22.3% | 16.7% | 15.8% |
| Single householder, no children | 12.9% | 11.3% | 10.8% |