| | Bluffton, SC | Siesta Key, FL | United States |
| Population | 27,596 | 5,416 | 329,725,481 |
| Female Population | 50.2% | 51.2% | 50.5% |
| Male Population | 49.8% | 48.8% | 49.5% |
| Median Age | 38.9 | 67.1 | 38.4 |
| space3 | | | |
| Population - 2010 | 13,053 | 6,573 | 309,327,143 |
| Population - 2000 | 1,275 | 7,150 | 285,036,114 |
| Population - 1990 | 738 | 7,772 | 251,960,433 |
| Pop. 2000 to Now | 2,114.1% | -10.4% | 15.6% |
| Pop. 1990 to Now | 3,725.2% | -17.6% | 30.8% |
| space4 | | | |
| Population Density | 531.0 | 2,311.6 | 93.4 |
| Land Area | 52.0 | 2.3 | 3,531,905.4 |
| Water Area | 2.2 | 1.1 | 264,836.8 |
| space | | | |
| Est. Total Population By Age | | | |
| | Bluffton, SC | Siesta Key, FL | United States |
| Age 0 to 4 | 5.1% | 1.0% | 5.9% |
| Age 5 to 9 | 6.8% | 0.5% | 6.1% |
| Age 10 to 14 | 9.4% | 2.2% | 6.6% |
| Age 15 to 17 | 5.4% | 2.7% | 3.9% |
| Age 18 to 20 | 2.7% | 0.6% | 4.0% |
| Age 21 to 24 | 2.9% | 2.1% | 5.2% |
| Age 25 to 34 | 11.7% | 3.0% | 13.8% |
| Age 35 to 44 | 15.2% | 3.3% | 12.9% |
| Age 45 to 54 | 11.7% | 8.4% | 12.6% |
| Age 55 to 59 | 4.9% | 10.3% | 6.7% |
| Age 60 to 64 | 5.4% | 11.0% | 6.3% |
| Age 65 to 74 | 12.8% | 24.9% | 9.6% |
| Age 75 to 84 | 4.0% | 22.9% | 4.5% |
| Age 85 and over | 2.0% | 7.1% | 1.9% |
| space1 | | | |
| Race | | | |
| | Bluffton, SC | Siesta Key, FL | United States |
| White | 74.4% | 92.9% | 59.4% |
| Black | 8.0% | 0.0% | 12.2% |
| Asian | 1.5% | 1.8% | 5.6% |
| Native American | 0.0% | 0.4% | 0.6% |
| Hawaiian, Pacific Islander | 0.0% | 0.0% | 0.2% |
| Other | 1.3% | 0.4% | 0.4% |
| Two or More Races | 2.4% | 1.8% | 3.2% |
| Hispanic | 12.4% | 2.7% | 18.4% |
| space2 | | | |
| Marriage & Family | | | |
| | Bluffton, SC | Siesta Key, FL | United States |
| Married Population | 62.2% | 66.0% | 49.8% |
| Currently Married | 60.9% | 65.3% | 48.0% |
| Married but Separated | 1.2% | 0.8% | 1.8% |
| Single Population | 37.8% | 34.0% | 50.2% |
| Never Married | 26.2% | 11.5% | 33.8% |
| Divorced | 8.2% | 11.8% | 10.8% |
| Widowed | 3.5% | 10.6% | 5.6% |
| space5 | | | |
| Household Size | 2.77 | 1.84 | 2.60 |
| Households | 9,924 | 2,948 | 124,010,992 |
| Family Households | 7,444 | 1,788 | 80,755,759 |
| Married couple, w/children | 33.4% | 7.6% | 30.5% |
| Married couple, no children | 51.2% | 84.8% | 42.9% |
| Non Family Households | 2,480 | 1,160 | 43,255,233 |
| Single householder, w/children | 9.6% | 3.1% | 15.8% |
| Single householder, no children | 5.8% | 4.4% | 10.8% |