| | Buffalo, NY | Anderson, SC | United States |
| Population | 276,011 | 28,796 | 329,725,481 |
| Female Population | 51.9% | 53.6% | 50.5% |
| Male Population | 48.1% | 46.4% | 49.5% |
| Median Age | 33.9 | 34.1 | 38.4 |
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| Population - 2010 | 261,280 | 26,433 | 309,327,143 |
| Population - 2000 | 292,648 | 25,514 | 285,036,114 |
| Population - 1990 | 328,123 | 26,184 | 251,960,433 |
| Pop. 2000 to Now | -13.0% | 8.6% | 15.6% |
| Pop. 1990 to Now | -22.4% | 5.8% | 30.8% |
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| Population Density | 6,835.7 | 1,984.0 | 93.4 |
| Land Area | 40.4 | 14.5 | 3,531,905.4 |
| Water Area | 12.1 | 0.0 | 264,836.8 |
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| Est. Total Population By Age | | | |
| | Buffalo, NY | Anderson, SC | United States |
| Age 0 to 4 | 6.4% | 5.9% | 5.9% |
| Age 5 to 9 | 6.4% | 6.7% | 6.1% |
| Age 10 to 14 | 6.0% | 6.5% | 6.6% |
| Age 15 to 17 | 3.7% | 4.2% | 3.9% |
| Age 18 to 20 | 4.8% | 5.9% | 4.0% |
| Age 21 to 24 | 6.5% | 6.4% | 5.2% |
| Age 25 to 34 | 17.9% | 15.7% | 13.8% |
| Age 35 to 44 | 12.0% | 9.7% | 12.9% |
| Age 45 to 54 | 10.9% | 10.7% | 12.6% |
| Age 55 to 59 | 6.2% | 6.9% | 6.7% |
| Age 60 to 64 | 6.2% | 4.7% | 6.3% |
| Age 65 to 74 | 8.1% | 8.6% | 9.6% |
| Age 75 to 84 | 3.3% | 5.4% | 4.5% |
| Age 85 and over | 1.6% | 2.7% | 1.9% |
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| Race | | | |
| | Buffalo, NY | Anderson, SC | United States |
| White | 44.7% | 59.4% | 59.4% |
| Black | 32.3% | 33.0% | 12.2% |
| Asian | 6.7% | 0.7% | 5.6% |
| Native American | 0.3% | 0.2% | 0.6% |
| Hawaiian, Pacific Islander | 0.0% | 0.1% | 0.2% |
| Other | 0.3% | 0.0% | 0.4% |
| Two or More Races | 3.5% | 2.9% | 3.2% |
| Hispanic | 12.2% | 3.8% | 18.4% |
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| Marriage & Family | | | |
| | Buffalo, NY | Anderson, SC | United States |
| Married Population | 32.0% | 37.8% | 49.8% |
| Currently Married | 29.5% | 34.5% | 48.0% |
| Married but Separated | 2.6% | 3.3% | 1.8% |
| Single Population | 68.0% | 62.2% | 50.2% |
| Never Married | 51.2% | 41.3% | 33.8% |
| Divorced | 11.2% | 11.0% | 10.8% |
| Widowed | 5.6% | 9.9% | 5.6% |
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| Household Size | 2.26 | 2.28 | 2.60 |
| Households | 118,071 | 11,907 | 124,010,992 |
| Family Households | 58,775 | 6,618 | 80,755,759 |
| Married couple, w/children | 21.6% | 19.9% | 30.5% |
| Married couple, no children | 28.6% | 35.4% | 42.9% |
| Non Family Households | 59,296 | 5,289 | 43,255,233 |
| Single householder, w/children | 30.5% | 27.5% | 15.8% |
| Single householder, no children | 19.3% | 17.2% | 10.8% |