| | Chillicothe, OH | Winston-Salem, NC | United States |
| Population | 22,047 | 247,917 | 329,725,481 |
| Female Population | 52.3% | 52.9% | 50.5% |
| Male Population | 47.7% | 47.1% | 49.5% |
| Median Age | 41.9 | 35.9 | 38.4 |
| space3 | | | |
| Population - 2010 | 21,902 | 230,024 | 309,327,143 |
| Population - 2000 | 21,796 | 185,776 | 285,036,114 |
| Population - 1990 | 21,923 | 143,485 | 251,960,433 |
| Pop. 2000 to Now | -0.7% | 33.6% | 15.6% |
| Pop. 1990 to Now | -1.3% | 72.9% | 30.8% |
| space4 | | | |
| Population Density | 2,115.4 | 1,870.3 | 93.4 |
| Land Area | 10.4 | 132.6 | 3,531,905.4 |
| Water Area | 0.2 | 1.2 | 264,836.8 |
| space | | | |
| Est. Total Population By Age | | | |
| | Chillicothe, OH | Winston-Salem, NC | United States |
| Age 0 to 4 | 6.2% | 6.0% | 5.9% |
| Age 5 to 9 | 5.7% | 6.0% | 6.1% |
| Age 10 to 14 | 6.7% | 7.0% | 6.6% |
| Age 15 to 17 | 2.3% | 4.3% | 3.9% |
| Age 18 to 20 | 2.9% | 5.9% | 4.0% |
| Age 21 to 24 | 4.7% | 5.2% | 5.2% |
| Age 25 to 34 | 11.2% | 14.4% | 13.8% |
| Age 35 to 44 | 14.2% | 12.2% | 12.9% |
| Age 45 to 54 | 12.3% | 12.3% | 12.6% |
| Age 55 to 59 | 5.9% | 6.4% | 6.7% |
| Age 60 to 64 | 7.2% | 6.0% | 6.3% |
| Age 65 to 74 | 11.8% | 8.5% | 9.6% |
| Age 75 to 84 | 6.0% | 4.0% | 4.5% |
| Age 85 and over | 2.8% | 1.7% | 1.9% |
| space1 | | | |
| Race | | | |
| | Chillicothe, OH | Winston-Salem, NC | United States |
| White | 84.3% | 45.0% | 59.4% |
| Black | 7.8% | 32.8% | 12.2% |
| Asian | 0.2% | 2.5% | 5.6% |
| Native American | 0.1% | 0.2% | 0.6% |
| Hawaiian, Pacific Islander | 0.0% | 0.1% | 0.2% |
| Other | 0.3% | 0.4% | 0.4% |
| Two or More Races | 6.0% | 2.9% | 3.2% |
| Hispanic | 1.2% | 16.2% | 18.4% |
| space2 | | | |
| Marriage & Family | | | |
| | Chillicothe, OH | Winston-Salem, NC | United States |
| Married Population | 45.5% | 41.7% | 49.8% |
| Currently Married | 43.4% | 39.1% | 48.0% |
| Married but Separated | 2.1% | 2.6% | 1.8% |
| Single Population | 54.5% | 58.3% | 50.2% |
| Never Married | 28.6% | 41.9% | 33.8% |
| Divorced | 18.0% | 11.0% | 10.8% |
| Widowed | 7.8% | 5.4% | 5.6% |
| space5 | | | |
| Household Size | 2.23 | 2.43 | 2.60 |
| Households | 9,534 | 97,869 | 124,010,992 |
| Family Households | 5,294 | 56,451 | 80,755,759 |
| Married couple, w/children | 25.1% | 26.2% | 30.5% |
| Married couple, no children | 40.8% | 38.6% | 42.9% |
| Non Family Households | 4,240 | 41,418 | 43,255,233 |
| Single householder, w/children | 23.0% | 23.1% | 15.8% |
| Single householder, no children | 11.1% | 12.1% | 10.8% |