| | Holyoke, MA | Santa Fe, NM | United States |
| Population | 38,480 | 86,935 | 329,725,481 |
| Female Population | 51.7% | 52.3% | 50.5% |
| Male Population | 48.3% | 47.7% | 49.5% |
| Median Age | 36.5 | 44 | 38.4 |
| space3 | | | |
| Population - 2010 | 39,917 | 81,021 | 309,327,143 |
| Population - 2000 | 39,838 | 62,203 | 285,036,114 |
| Population - 1990 | 43,704 | 55,859 | 251,960,433 |
| Pop. 2000 to Now | 0.2% | 36.6% | 15.6% |
| Pop. 1990 to Now | -8.7% | 52.2% | 30.8% |
| space4 | | | |
| Population Density | 1,818.1 | 1,665.9 | 93.4 |
| Land Area | 21.2 | 52.2 | 3,531,905.4 |
| Water Area | 1.6 | 0.2 | 264,836.8 |
| space | | | |
| Est. Total Population By Age | | | |
| | Holyoke, MA | Santa Fe, NM | United States |
| Age 0 to 4 | 6.4% | 4.3% | 5.9% |
| Age 5 to 9 | 5.8% | 4.8% | 6.1% |
| Age 10 to 14 | 7.0% | 5.7% | 6.6% |
| Age 15 to 17 | 4.2% | 3.4% | 3.9% |
| Age 18 to 20 | 4.0% | 3.6% | 4.0% |
| Age 21 to 24 | 5.6% | 4.8% | 5.2% |
| Age 25 to 34 | 15.3% | 12.0% | 13.8% |
| Age 35 to 44 | 11.7% | 12.4% | 12.9% |
| Age 45 to 54 | 12.4% | 12.4% | 12.6% |
| Age 55 to 59 | 5.8% | 6.6% | 6.7% |
| Age 60 to 64 | 6.1% | 6.1% | 6.3% |
| Age 65 to 74 | 8.5% | 14.9% | 9.6% |
| Age 75 to 84 | 4.2% | 6.6% | 4.5% |
| Age 85 and over | 3.2% | 2.3% | 1.9% |
| space1 | | | |
| Race | | | |
| | Holyoke, MA | Santa Fe, NM | United States |
| White | 42.0% | 39.5% | 59.4% |
| Black | 2.3% | 1.0% | 12.2% |
| Asian | 0.8% | 1.5% | 5.6% |
| Native American | 0.1% | 1.1% | 0.6% |
| Hawaiian, Pacific Islander | 0.0% | 0.2% | 0.2% |
| Other | 0.1% | 0.4% | 0.4% |
| Two or More Races | 1.5% | 1.9% | 3.2% |
| Hispanic | 53.3% | 54.3% | 18.4% |
| space2 | | | |
| Marriage & Family | | | |
| | Holyoke, MA | Santa Fe, NM | United States |
| Married Population | 33.9% | 42.9% | 49.8% |
| Currently Married | 31.7% | 41.6% | 48.0% |
| Married but Separated | 2.2% | 1.3% | 1.8% |
| Single Population | 66.1% | 57.1% | 50.2% |
| Never Married | 51.6% | 34.0% | 33.8% |
| Divorced | 9.6% | 17.9% | 10.8% |
| Widowed | 4.9% | 5.2% | 5.6% |
| space5 | | | |
| Household Size | 2.48 | 2.26 | 2.60 |
| Households | 15,062 | 37,878 | 124,010,992 |
| Family Households | 9,182 | 20,781 | 80,755,759 |
| Married couple, w/children | 15.4% | 24.3% | 30.5% |
| Married couple, no children | 32.1% | 44.2% | 42.9% |
| Non Family Households | 5,880 | 17,097 | 43,255,233 |
| Single householder, w/children | 33.6% | 18.6% | 15.8% |
| Single householder, no children | 18.9% | 13.0% | 10.8% |