| | Madison, NC | Greenwood, SC | United States |
| Population | 2,244 | 22,363 | 329,725,481 |
| Female Population | 51.7% | 52.5% | 50.5% |
| Male Population | 48.3% | 47.5% | 49.5% |
| Median Age | 50.3 | 34 | 38.4 |
| space3 | | | |
| Population - 2010 | 2,240 | 23,233 | 309,327,143 |
| Population - 2000 | 2,262 | 22,071 | 285,036,114 |
| Population - 1990 | 2,371 | 20,807 | 251,960,433 |
| Pop. 2000 to Now | -6.8% | 5.8% | 15.6% |
| Pop. 1990 to Now | -11.1% | 12.3% | 30.8% |
| space4 | | | |
| Population Density | 633.9 | 1,370.1 | 93.4 |
| Land Area | 3.5 | 16.3 | 3,531,905.4 |
| Water Area | 0.0 | 0.1 | 264,836.8 |
| space | | | |
| Est. Total Population By Age | | | |
| | Madison, NC | Greenwood, SC | United States |
| Age 0 to 4 | 3.7% | 7.4% | 5.9% |
| Age 5 to 9 | 4.2% | 7.5% | 6.1% |
| Age 10 to 14 | 3.6% | 6.9% | 6.6% |
| Age 15 to 17 | 2.5% | 2.8% | 3.9% |
| Age 18 to 20 | 2.6% | 7.1% | 4.0% |
| Age 21 to 24 | 5.8% | 7.4% | 5.2% |
| Age 25 to 34 | 12.3% | 11.7% | 13.8% |
| Age 35 to 44 | 7.8% | 13.0% | 12.9% |
| Age 45 to 54 | 14.3% | 9.8% | 12.6% |
| Age 55 to 59 | 12.9% | 5.9% | 6.7% |
| Age 60 to 64 | 7.9% | 5.6% | 6.3% |
| Age 65 to 74 | 10.8% | 6.9% | 9.6% |
| Age 75 to 84 | 7.4% | 5.4% | 4.5% |
| Age 85 and over | 4.0% | 2.8% | 1.9% |
| space1 | | | |
| Race | | | |
| | Madison, NC | Greenwood, SC | United States |
| White | 66.6% | 38.6% | 59.4% |
| Black | 21.7% | 49.6% | 12.2% |
| Asian | 0.0% | 0.8% | 5.6% |
| Native American | 0.1% | 0.1% | 0.6% |
| Hawaiian, Pacific Islander | 0.0% | 0.0% | 0.2% |
| Other | 0.0% | 0.4% | 0.4% |
| Two or More Races | 1.5% | 0.4% | 3.2% |
| Hispanic | 10.0% | 10.2% | 18.4% |
| space2 | | | |
| Marriage & Family | | | |
| | Madison, NC | Greenwood, SC | United States |
| Married Population | 45.3% | 32.0% | 49.8% |
| Currently Married | 42.1% | 29.1% | 48.0% |
| Married but Separated | 3.3% | 2.9% | 1.8% |
| Single Population | 54.7% | 68.0% | 50.2% |
| Never Married | 31.8% | 47.9% | 33.8% |
| Divorced | 12.9% | 11.1% | 10.8% |
| Widowed | 9.9% | 9.0% | 5.6% |
| space5 | | | |
| Household Size | 2.22 | 2.32 | 2.60 |
| Households | 1,005 | 8,818 | 124,010,992 |
| Family Households | 592 | 4,306 | 80,755,759 |
| Married couple, w/children | 19.9% | 20.1% | 30.5% |
| Married couple, no children | 49.0% | 32.9% | 42.9% |
| Non Family Households | 413 | 4,512 | 43,255,233 |
| Single householder, w/children | 10.3% | 33.9% | 15.8% |
| Single householder, no children | 20.8% | 13.1% | 10.8% |