| | Manasota Key, FL | Fort Myers Beach, FL | United States |
| Population | 1,619 | 5,687 | 329,725,481 |
| Female Population | 54.2% | 52.6% | 50.5% |
| Male Population | 45.8% | 47.4% | 49.5% |
| Median Age | 72 | 65.4 | 38.4 |
| space3 | | | |
| Population - 2010 | 1,034 | 6,288 | 309,327,143 |
| Population - 2000 | 1,345 | 6,561 | 285,036,114 |
| Population - 1990 | 1,395 | 9,284 | 251,960,433 |
| Pop. 2000 to Now | -7.7% | 8.5% | 15.6% |
| Pop. 1990 to Now | -11.0% | -23.3% | 30.8% |
| space4 | | | |
| Population Density | 1,549.3 | 2,044.2 | 93.4 |
| Land Area | 1.0 | 2.8 | 3,531,905.4 |
| Water Area | 2.0 | 3.4 | 264,836.8 |
| space | | | |
| Est. Total Population By Age | | | |
| | Manasota Key, FL | Fort Myers Beach, FL | United States |
| Age 0 to 4 | 0.0% | 1.2% | 5.9% |
| Age 5 to 9 | 0.0% | 0.8% | 6.1% |
| Age 10 to 14 | 0.9% | 1.1% | 6.6% |
| Age 15 to 17 | 0.0% | 1.1% | 3.9% |
| Age 18 to 20 | 0.8% | 1.1% | 4.0% |
| Age 21 to 24 | 1.9% | 2.7% | 5.2% |
| Age 25 to 34 | 0.0% | 4.1% | 13.8% |
| Age 35 to 44 | 1.4% | 3.3% | 12.9% |
| Age 45 to 54 | 5.1% | 11.1% | 12.6% |
| Age 55 to 59 | 9.1% | 8.1% | 6.7% |
| Age 60 to 64 | 12.4% | 13.9% | 6.3% |
| Age 65 to 74 | 33.2% | 29.0% | 9.6% |
| Age 75 to 84 | 29.5% | 17.7% | 4.5% |
| Age 85 and over | 5.7% | 4.6% | 1.9% |
| space1 | | | |
| Race | | | |
| | Manasota Key, FL | Fort Myers Beach, FL | United States |
| White | 100.0% | 93.8% | 59.4% |
| Black | 0.0% | 0.2% | 12.2% |
| Asian | 0.0% | 1.3% | 5.6% |
| Native American | 0.0% | 0.0% | 0.6% |
| Hawaiian, Pacific Islander | 0.0% | 0.0% | 0.2% |
| Other | 0.0% | 0.0% | 0.4% |
| Two or More Races | 0.0% | 0.0% | 3.2% |
| Hispanic | 0.0% | 4.7% | 18.4% |
| space2 | | | |
| Marriage & Family | | | |
| | Manasota Key, FL | Fort Myers Beach, FL | United States |
| Married Population | 72.2% | 62.9% | 49.8% |
| Currently Married | 72.2% | 62.7% | 48.0% |
| Married but Separated | 0.0% | 0.2% | 1.8% |
| Single Population | 27.8% | 37.1% | 50.2% |
| Never Married | 5.4% | 16.0% | 33.8% |
| Divorced | 14.0% | 12.6% | 10.8% |
| Widowed | 8.3% | 8.6% | 5.6% |
| space5 | | | |
| Household Size | 1.83 | 2.05 | 2.60 |
| Households | 886 | 2,757 | 124,010,992 |
| Family Households | 610 | 1,789 | 80,755,759 |
| Married couple, w/children | 1.8% | 3.7% | 30.5% |
| Married couple, no children | 94.1% | 90.6% | 42.9% |
| Non Family Households | 276 | 968 | 43,255,233 |
| Single householder, w/children | 0.0% | 1.0% | 15.8% |
| Single householder, no children | 4.1% | 4.6% | 10.8% |