| | Mayfield Heights, OH | Palo Alto, CA | United States |
| Population | 20,113 | 68,624 | 329,725,481 |
| Female Population | 53.4% | 51.6% | 50.5% |
| Male Population | 46.6% | 48.4% | 49.5% |
| Median Age | 38.6 | 41.8 | 38.4 |
| space3 | | | |
| Population - 2010 | 19,124 | 64,506 | 309,327,143 |
| Population - 2000 | 19,386 | 58,598 | 285,036,114 |
| Population - 1990 | 19,847 | 55,900 | 251,960,433 |
| Pop. 2000 to Now | -5.2% | 14.4% | 15.6% |
| Pop. 1990 to Now | -7.4% | 19.9% | 30.8% |
| space4 | | | |
| Population Density | 4,823.3 | 2,875.2 | 93.4 |
| Land Area | 4.2 | 23.9 | 3,531,905.4 |
| Water Area | 0.0 | 1.9 | 264,836.8 |
| space | | | |
| Est. Total Population By Age | | | |
| | Mayfield Heights, OH | Palo Alto, CA | United States |
| Age 0 to 4 | 6.4% | 4.7% | 5.9% |
| Age 5 to 9 | 4.7% | 5.6% | 6.1% |
| Age 10 to 14 | 5.4% | 7.6% | 6.6% |
| Age 15 to 17 | 2.2% | 5.0% | 3.9% |
| Age 18 to 20 | 2.0% | 2.8% | 4.0% |
| Age 21 to 24 | 4.2% | 3.7% | 5.2% |
| Age 25 to 34 | 18.5% | 12.2% | 13.8% |
| Age 35 to 44 | 15.1% | 12.1% | 12.9% |
| Age 45 to 54 | 10.1% | 14.7% | 12.6% |
| Age 55 to 59 | 6.3% | 7.4% | 6.7% |
| Age 60 to 64 | 3.6% | 5.6% | 6.3% |
| Age 65 to 74 | 10.2% | 8.3% | 9.6% |
| Age 75 to 84 | 7.5% | 6.0% | 4.5% |
| Age 85 and over | 3.8% | 4.2% | 1.9% |
| space1 | | | |
| Race | | | |
| | Mayfield Heights, OH | Palo Alto, CA | United States |
| White | 68.8% | 50.0% | 59.4% |
| Black | 15.1% | 2.1% | 12.2% |
| Asian | 4.2% | 35.0% | 5.6% |
| Native American | 0.0% | 0.1% | 0.6% |
| Hawaiian, Pacific Islander | 0.0% | 0.1% | 0.2% |
| Other | 0.3% | 0.4% | 0.4% |
| Two or More Races | 5.5% | 5.4% | 3.2% |
| Hispanic | 6.1% | 7.0% | 18.4% |
| space2 | | | |
| Marriage & Family | | | |
| | Mayfield Heights, OH | Palo Alto, CA | United States |
| Married Population | 44.3% | 58.5% | 49.8% |
| Currently Married | 43.5% | 57.8% | 48.0% |
| Married but Separated | 0.9% | 0.7% | 1.8% |
| Single Population | 55.7% | 41.5% | 50.2% |
| Never Married | 30.3% | 29.6% | 33.8% |
| Divorced | 17.4% | 7.1% | 10.8% |
| Widowed | 7.9% | 4.8% | 5.6% |
| space5 | | | |
| Household Size | 2.00 | 2.62 | 2.60 |
| Households | 9,983 | 26,007 | 124,010,992 |
| Family Households | 4,901 | 17,570 | 80,755,759 |
| Married couple, w/children | 34.6% | 43.2% | 30.5% |
| Married couple, no children | 35.8% | 43.7% | 42.9% |
| Non Family Households | 5,082 | 8,437 | 43,255,233 |
| Single householder, w/children | 15.3% | 6.7% | 15.8% |
| Single householder, no children | 14.3% | 6.5% | 10.8% |