| | Natick, MA | Melrose, MA | United States |
| Population | 36,627 | 29,567 | 329,725,481 |
| Female Population | 51.7% | 51.7% | 50.5% |
| Male Population | 48.3% | 48.3% | 49.5% |
| Median Age | 42.3 | 42.1 | 38.4 |
| space3 | | | |
| Population - 2010 | 33,100 | 27,041 | 309,327,143 |
| Population - 2000 | 32,170 | 27,134 | 285,036,114 |
| Population - 1990 | 30,510 | 28,150 | 251,960,433 |
| Pop. 2000 to Now | 11.2% | 2.4% | 15.6% |
| Pop. 1990 to Now | 17.2% | -1.3% | 30.8% |
| space4 | | | |
| Population Density | 2,449.3 | 6,313.7 | 93.4 |
| Land Area | 15.0 | 4.7 | 3,531,905.4 |
| Water Area | 1.0 | 0.1 | 264,836.8 |
| space | | | |
| Est. Total Population By Age | | | |
| | Natick, MA | Melrose, MA | United States |
| Age 0 to 4 | 5.3% | 5.8% | 5.9% |
| Age 5 to 9 | 7.1% | 6.5% | 6.1% |
| Age 10 to 14 | 5.5% | 4.1% | 6.6% |
| Age 15 to 17 | 4.3% | 3.6% | 3.9% |
| Age 18 to 20 | 1.9% | 2.2% | 4.0% |
| Age 21 to 24 | 3.2% | 4.2% | 5.2% |
| Age 25 to 34 | 12.9% | 11.7% | 13.8% |
| Age 35 to 44 | 13.0% | 16.2% | 12.9% |
| Age 45 to 54 | 14.9% | 15.4% | 12.6% |
| Age 55 to 59 | 7.0% | 6.1% | 6.7% |
| Age 60 to 64 | 7.2% | 5.6% | 6.3% |
| Age 65 to 74 | 10.6% | 9.1% | 9.6% |
| Age 75 to 84 | 4.7% | 6.9% | 4.5% |
| Age 85 and over | 2.5% | 2.6% | 1.9% |
| space1 | | | |
| Race | | | |
| | Natick, MA | Melrose, MA | United States |
| White | 76.9% | 80.8% | 59.4% |
| Black | 1.9% | 3.4% | 12.2% |
| Asian | 14.0% | 8.3% | 5.6% |
| Native American | 0.2% | 0.0% | 0.6% |
| Hawaiian, Pacific Islander | 0.0% | 0.0% | 0.2% |
| Other | 0.2% | 0.3% | 0.4% |
| Two or More Races | 2.8% | 3.7% | 3.2% |
| Hispanic | 4.0% | 3.5% | 18.4% |
| space2 | | | |
| Marriage & Family | | | |
| | Natick, MA | Melrose, MA | United States |
| Married Population | 59.7% | 57.6% | 49.8% |
| Currently Married | 58.1% | 56.6% | 48.0% |
| Married but Separated | 1.6% | 1.0% | 1.8% |
| Single Population | 40.3% | 42.4% | 50.2% |
| Never Married | 25.7% | 29.5% | 33.8% |
| Divorced | 9.4% | 7.9% | 10.8% |
| Widowed | 5.2% | 5.0% | 5.6% |
| space5 | | | |
| Household Size | 2.38 | 2.44 | 2.60 |
| Households | 15,243 | 11,996 | 124,010,992 |
| Family Households | 10,143 | 7,805 | 80,755,759 |
| Married couple, w/children | 39.6% | 40.7% | 30.5% |
| Married couple, no children | 44.3% | 45.7% | 42.9% |
| Non Family Households | 5,100 | 4,191 | 43,255,233 |
| Single householder, w/children | 8.1% | 4.6% | 15.8% |
| Single householder, no children | 8.0% | 9.1% | 10.8% |