| | Prestonsburg, KY | Greencastle, IN | United States |
| Population | 4,099 | 9,980 | 329,725,481 |
| Female Population | 48.0% | 50.6% | 50.5% |
| Male Population | 52.0% | 49.4% | 49.5% |
| Median Age | 34.1 | 25.4 | 38.4 |
| space3 | | | |
| Population - 2010 | 3,845 | 10,300 | 309,327,143 |
| Population - 2000 | 3,612 | 9,880 | 285,036,114 |
| Population - 1990 | 3,558 | 8,984 | 251,960,433 |
| Pop. 2000 to Now | -4.2% | 4.6% | 15.6% |
| Pop. 1990 to Now | -2.8% | 15.1% | 30.8% |
| space4 | | | |
| Population Density | 283.2 | 1,903.9 | 93.4 |
| Land Area | 14.5 | 5.2 | 3,531,905.4 |
| Water Area | 0.2 | 0.1 | 264,836.8 |
| space | | | |
| Est. Total Population By Age | | | |
| | Prestonsburg, KY | Greencastle, IN | United States |
| Age 0 to 4 | 7.3% | 4.3% | 5.9% |
| Age 5 to 9 | 6.8% | 6.4% | 6.1% |
| Age 10 to 14 | 5.3% | 5.5% | 6.6% |
| Age 15 to 17 | 2.9% | 2.0% | 3.9% |
| Age 18 to 20 | 11.3% | 18.9% | 4.0% |
| Age 21 to 24 | 4.9% | 12.4% | 5.2% |
| Age 25 to 34 | 12.8% | 11.5% | 13.8% |
| Age 35 to 44 | 12.3% | 9.8% | 12.9% |
| Age 45 to 54 | 9.2% | 6.9% | 12.6% |
| Age 55 to 59 | 4.0% | 3.1% | 6.7% |
| Age 60 to 64 | 4.6% | 4.7% | 6.3% |
| Age 65 to 74 | 11.2% | 6.0% | 9.6% |
| Age 75 to 84 | 3.5% | 5.4% | 4.5% |
| Age 85 and over | 4.0% | 3.1% | 1.9% |
| space1 | | | |
| Race | | | |
| | Prestonsburg, KY | Greencastle, IN | United States |
| White | 93.7% | 87.7% | 59.4% |
| Black | 3.7% | 1.8% | 12.2% |
| Asian | 0.7% | 5.5% | 5.6% |
| Native American | 0.0% | 0.2% | 0.6% |
| Hawaiian, Pacific Islander | 0.0% | 0.1% | 0.2% |
| Other | 0.0% | 0.0% | 0.4% |
| Two or More Races | 1.7% | 1.9% | 3.2% |
| Hispanic | 0.2% | 2.7% | 18.4% |
| space2 | | | |
| Marriage & Family | | | |
| | Prestonsburg, KY | Greencastle, IN | United States |
| Married Population | 48.4% | 32.8% | 49.8% |
| Currently Married | 44.2% | 31.3% | 48.0% |
| Married but Separated | 4.2% | 1.5% | 1.8% |
| Single Population | 51.6% | 67.2% | 50.2% |
| Never Married | 31.0% | 51.5% | 33.8% |
| Divorced | 12.1% | 9.5% | 10.8% |
| Widowed | 8.6% | 6.2% | 5.6% |
| space5 | | | |
| Household Size | 2.43 | 2.10 | 2.60 |
| Households | 1,434 | 3,446 | 124,010,992 |
| Family Households | 960 | 1,897 | 80,755,759 |
| Married couple, w/children | 30.1% | 26.1% | 30.5% |
| Married couple, no children | 42.1% | 38.3% | 42.9% |
| Non Family Households | 474 | 1,549 | 43,255,233 |
| Single householder, w/children | 22.3% | 24.9% | 15.8% |
| Single householder, no children | 5.5% | 10.6% | 10.8% |