| | Tampa, FL | Clayton, MO | United States |
| Population | 380,476 | 16,905 | 329,725,481 |
| Female Population | 50.4% | 51.3% | 50.5% |
| Male Population | 49.6% | 48.7% | 49.5% |
| Median Age | 35.9 | 29.2 | 38.4 |
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| Population - 2010 | 337,156 | 15,974 | 309,327,143 |
| Population - 2000 | 303,447 | 12,825 | 285,036,114 |
| Population - 1990 | 280,015 | 13,874 | 251,960,433 |
| Pop. 2000 to Now | 34.3% | 30.8% | 15.6% |
| Pop. 1990 to Now | 45.6% | 20.9% | 30.8% |
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| Population Density | 3,337.4 | 6,737.7 | 93.4 |
| Land Area | 114.0 | 2.5 | 3,531,905.4 |
| Water Area | 61.8 | 0.0 | 264,836.8 |
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| Est. Total Population By Age | | | |
| | Tampa, FL | Clayton, MO | United States |
| Age 0 to 4 | 6.2% | 3.3% | 5.9% |
| Age 5 to 9 | 5.9% | 4.7% | 6.1% |
| Age 10 to 14 | 5.9% | 6.5% | 6.6% |
| Age 15 to 17 | 3.5% | 3.5% | 3.9% |
| Age 18 to 20 | 4.6% | 20.3% | 4.0% |
| Age 21 to 24 | 5.4% | 7.8% | 5.2% |
| Age 25 to 34 | 17.2% | 9.9% | 13.8% |
| Age 35 to 44 | 13.9% | 10.8% | 12.9% |
| Age 45 to 54 | 13.0% | 11.2% | 12.6% |
| Age 55 to 59 | 5.9% | 5.8% | 6.7% |
| Age 60 to 64 | 5.7% | 4.3% | 6.3% |
| Age 65 to 74 | 7.6% | 6.5% | 9.6% |
| Age 75 to 84 | 3.8% | 3.9% | 4.5% |
| Age 85 and over | 1.4% | 1.7% | 1.9% |
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| Race | | | |
| | Tampa, FL | Clayton, MO | United States |
| White | 44.4% | 72.8% | 59.4% |
| Black | 21.1% | 7.7% | 12.2% |
| Asian | 4.5% | 10.7% | 5.6% |
| Native American | 0.1% | 0.1% | 0.6% |
| Hawaiian, Pacific Islander | 0.1% | 0.0% | 0.2% |
| Other | 0.3% | 0.7% | 0.4% |
| Two or More Races | 3.3% | 4.8% | 3.2% |
| Hispanic | 26.2% | 3.3% | 18.4% |
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| Marriage & Family | | | |
| | Tampa, FL | Clayton, MO | United States |
| Married Population | 41.6% | 40.2% | 49.8% |
| Currently Married | 39.1% | 39.9% | 48.0% |
| Married but Separated | 2.5% | 0.3% | 1.8% |
| Single Population | 58.4% | 59.8% | 50.2% |
| Never Married | 40.3% | 50.7% | 33.8% |
| Divorced | 13.1% | 5.9% | 10.8% |
| Widowed | 5.0% | 3.2% | 5.6% |
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| Household Size | 2.41 | 2.23 | 2.60 |
| Households | 153,163 | 5,566 | 124,010,992 |
| Family Households | 82,968 | 3,213 | 80,755,759 |
| Married couple, w/children | 28.0% | 39.2% | 30.5% |
| Married couple, no children | 37.3% | 45.5% | 42.9% |
| Non Family Households | 70,195 | 2,353 | 43,255,233 |
| Single householder, w/children | 21.0% | 11.6% | 15.8% |
| Single householder, no children | 13.7% | 3.7% | 10.8% |