| | Tarpon Springs, FL | Safety Harbor, FL | United States |
| Population | 25,138 | 17,093 | 329,725,481 |
| Female Population | 51.9% | 51.6% | 50.5% |
| Male Population | 48.1% | 48.4% | 49.5% |
| Median Age | 53 | 47.1 | 38.4 |
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| Population - 2010 | 23,491 | 16,898 | 309,327,143 |
| Population - 2000 | 21,003 | 17,203 | 285,036,114 |
| Population - 1990 | 17,906 | 15,124 | 251,960,433 |
| Pop. 2000 to Now | 22.0% | 4.4% | 15.6% |
| Pop. 1990 to Now | 43.1% | 18.8% | 30.8% |
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| Population Density | 2,754.6 | 3,473.5 | 93.4 |
| Land Area | 9.1 | 4.9 | 3,531,905.4 |
| Water Area | 8.6 | 0.2 | 264,836.8 |
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| Est. Total Population By Age | | | |
| | Tarpon Springs, FL | Safety Harbor, FL | United States |
| Age 0 to 4 | 4.2% | 6.4% | 5.9% |
| Age 5 to 9 | 4.1% | 5.7% | 6.1% |
| Age 10 to 14 | 4.3% | 5.4% | 6.6% |
| Age 15 to 17 | 3.3% | 4.0% | 3.9% |
| Age 18 to 20 | 1.8% | 2.8% | 4.0% |
| Age 21 to 24 | 3.2% | 2.5% | 5.2% |
| Age 25 to 34 | 8.7% | 9.4% | 13.8% |
| Age 35 to 44 | 10.1% | 12.2% | 12.9% |
| Age 45 to 54 | 13.3% | 15.6% | 12.6% |
| Age 55 to 59 | 9.5% | 8.2% | 6.7% |
| Age 60 to 64 | 8.1% | 7.8% | 6.3% |
| Age 65 to 74 | 15.6% | 11.7% | 9.6% |
| Age 75 to 84 | 9.9% | 6.4% | 4.5% |
| Age 85 and over | 4.0% | 2.1% | 1.9% |
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| Race | | | |
| | Tarpon Springs, FL | Safety Harbor, FL | United States |
| White | 78.0% | 82.3% | 59.4% |
| Black | 6.6% | 5.1% | 12.2% |
| Asian | 0.6% | 2.0% | 5.6% |
| Native American | 0.0% | 0.1% | 0.6% |
| Hawaiian, Pacific Islander | 0.1% | 0.1% | 0.2% |
| Other | 0.7% | 0.3% | 0.4% |
| Two or More Races | 2.5% | 2.5% | 3.2% |
| Hispanic | 11.4% | 7.8% | 18.4% |
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| Marriage & Family | | | |
| | Tarpon Springs, FL | Safety Harbor, FL | United States |
| Married Population | 52.4% | 53.8% | 49.8% |
| Currently Married | 50.2% | 53.1% | 48.0% |
| Married but Separated | 2.2% | 0.7% | 1.8% |
| Single Population | 47.6% | 46.2% | 50.2% |
| Never Married | 25.7% | 25.1% | 33.8% |
| Divorced | 12.0% | 13.2% | 10.8% |
| Widowed | 9.9% | 7.9% | 5.6% |
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| Household Size | 2.27 | 2.53 | 2.60 |
| Households | 10,897 | 6,693 | 124,010,992 |
| Family Households | 6,308 | 4,626 | 80,755,759 |
| Married couple, w/children | 21.8% | 28.6% | 30.5% |
| Married couple, no children | 58.6% | 49.6% | 42.9% |
| Non Family Households | 4,589 | 2,067 | 43,255,233 |
| Single householder, w/children | 10.2% | 11.7% | 15.8% |
| Single householder, no children | 9.4% | 10.1% | 10.8% |