| | Wesley Chapel, FL | Palmetto, FL | United States |
| Population | 65,134 | 13,304 | 329,725,481 |
| Female Population | 52.1% | 51.4% | 50.5% |
| Male Population | 47.9% | 48.6% | 49.5% |
| Median Age | 36.6 | 49.1 | 38.4 |
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| Population - 2010 | 39,309 | 12,674 | 309,327,143 |
| Population - 2000 | 5,691 | 12,571 | 285,036,114 |
| Population - 1990 | 6,437 | 9,268 | 251,960,433 |
| Pop. 2000 to Now | 981.3% | 9.7% | 15.6% |
| Pop. 1990 to Now | 856.0% | 48.9% | 30.8% |
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| Population Density | 1,483.0 | 2,509.2 | 93.4 |
| Land Area | 43.9 | 5.3 | 3,531,905.4 |
| Water Area | 0.1 | 0.5 | 264,836.8 |
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| Est. Total Population By Age | | | |
| | Wesley Chapel, FL | Palmetto, FL | United States |
| Age 0 to 4 | 5.9% | 4.7% | 5.9% |
| Age 5 to 9 | 7.3% | 6.6% | 6.1% |
| Age 10 to 14 | 8.1% | 7.0% | 6.6% |
| Age 15 to 17 | 4.8% | 2.5% | 3.9% |
| Age 18 to 20 | 3.4% | 1.5% | 4.0% |
| Age 21 to 24 | 5.6% | 4.6% | 5.2% |
| Age 25 to 34 | 11.8% | 12.5% | 13.8% |
| Age 35 to 44 | 15.8% | 7.8% | 12.9% |
| Age 45 to 54 | 16.3% | 11.5% | 12.6% |
| Age 55 to 59 | 5.3% | 6.7% | 6.7% |
| Age 60 to 64 | 4.6% | 8.0% | 6.3% |
| Age 65 to 74 | 6.4% | 12.1% | 9.6% |
| Age 75 to 84 | 3.7% | 11.3% | 4.5% |
| Age 85 and over | 0.9% | 3.1% | 1.9% |
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| Race | | | |
| | Wesley Chapel, FL | Palmetto, FL | United States |
| White | 55.4% | 56.6% | 59.4% |
| Black | 9.8% | 16.6% | 12.2% |
| Asian | 6.2% | 2.1% | 5.6% |
| Native American | 0.2% | 0.1% | 0.6% |
| Hawaiian, Pacific Islander | 0.1% | 0.0% | 0.2% |
| Other | 0.8% | 0.1% | 0.4% |
| Two or More Races | 3.5% | 0.8% | 3.2% |
| Hispanic | 24.0% | 23.8% | 18.4% |
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| Marriage & Family | | | |
| | Wesley Chapel, FL | Palmetto, FL | United States |
| Married Population | 56.1% | 50.4% | 49.8% |
| Currently Married | 54.6% | 48.2% | 48.0% |
| Married but Separated | 1.5% | 2.2% | 1.8% |
| Single Population | 43.9% | 49.6% | 50.2% |
| Never Married | 30.4% | 28.8% | 33.8% |
| Divorced | 9.8% | 11.9% | 10.8% |
| Widowed | 3.6% | 8.9% | 5.6% |
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| Household Size | 2.97 | 2.73 | 2.60 |
| Households | 21,946 | 4,796 | 124,010,992 |
| Family Households | 16,510 | 3,111 | 80,755,759 |
| Married couple, w/children | 42.8% | 15.3% | 30.5% |
| Married couple, no children | 35.5% | 60.2% | 42.9% |
| Non Family Households | 5,436 | 1,685 | 43,255,233 |
| Single householder, w/children | 14.1% | 13.0% | 15.8% |
| Single householder, no children | 7.7% | 11.5% | 10.8% |