| | Brenham, TX | McKinney, TX | United States |
| Population | 17,385 | 189,394 | 329,725,481 |
| Female Population | 54.6% | 50.7% | 50.5% |
| Male Population | 45.4% | 49.3% | 49.5% |
| Median Age | 35 | 36.9 | 38.4 |
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| Population - 2010 | 15,835 | 132,940 | 309,327,143 |
| Population - 2000 | 13,507 | 54,369 | 285,036,114 |
| Population - 1990 | 11,952 | 21,283 | 251,960,433 |
| Pop. 2000 to Now | 31.3% | 283.1% | 15.6% |
| Pop. 1990 to Now | 48.4% | 878.6% | 30.8% |
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| Population Density | 1,342.0 | 2,829.6 | 93.4 |
| Land Area | 13.0 | 66.9 | 3,531,905.4 |
| Water Area | 0.1 | 0.7 | 264,836.8 |
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| Est. Total Population By Age | | | |
| | Brenham, TX | McKinney, TX | United States |
| Age 0 to 4 | 5.4% | 6.7% | 5.9% |
| Age 5 to 9 | 6.8% | 8.6% | 6.1% |
| Age 10 to 14 | 6.6% | 8.7% | 6.6% |
| Age 15 to 17 | 4.0% | 4.7% | 3.9% |
| Age 18 to 20 | 10.9% | 3.6% | 4.0% |
| Age 21 to 24 | 6.7% | 3.9% | 5.2% |
| Age 25 to 34 | 9.6% | 11.1% | 13.8% |
| Age 35 to 44 | 11.1% | 18.0% | 12.9% |
| Age 45 to 54 | 9.2% | 14.6% | 12.6% |
| Age 55 to 59 | 5.4% | 5.8% | 6.7% |
| Age 60 to 64 | 5.9% | 4.3% | 6.3% |
| Age 65 to 74 | 8.0% | 5.9% | 9.6% |
| Age 75 to 84 | 7.2% | 3.0% | 4.5% |
| Age 85 and over | 3.2% | 1.1% | 1.9% |
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| Race | | | |
| | Brenham, TX | McKinney, TX | United States |
| White | 47.7% | 56.8% | 59.4% |
| Black | 22.6% | 11.8% | 12.2% |
| Asian | 1.7% | 10.7% | 5.6% |
| Native American | 0.0% | 0.3% | 0.6% |
| Hawaiian, Pacific Islander | 0.0% | 0.0% | 0.2% |
| Other | 0.3% | 0.3% | 0.4% |
| Two or More Races | 2.6% | 3.2% | 3.2% |
| Hispanic | 25.1% | 16.9% | 18.4% |
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| Marriage & Family | | | |
| | Brenham, TX | McKinney, TX | United States |
| Married Population | 43.5% | 61.4% | 49.8% |
| Currently Married | 42.4% | 60.1% | 48.0% |
| Married but Separated | 1.1% | 1.3% | 1.8% |
| Single Population | 56.5% | 38.6% | 50.2% |
| Never Married | 37.8% | 25.9% | 33.8% |
| Divorced | 12.8% | 9.1% | 10.8% |
| Widowed | 5.9% | 3.6% | 5.6% |
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| Household Size | 2.36 | 2.86 | 2.60 |
| Households | 6,476 | 65,770 | 124,010,992 |
| Family Households | 3,755 | 50,446 | 80,755,759 |
| Married couple, w/children | 31.4% | 45.7% | 30.5% |
| Married couple, no children | 40.4% | 35.7% | 42.9% |
| Non Family Households | 2,721 | 15,324 | 43,255,233 |
| Single householder, w/children | 19.0% | 12.3% | 15.8% |
| Single householder, no children | 9.2% | 6.2% | 10.8% |