| | Mequon, WI | De Pere, WI | United States |
| Population | 24,814 | 25,216 | 329,725,481 |
| Female Population | 51.3% | 53.5% | 50.5% |
| Male Population | 48.7% | 46.5% | 49.5% |
| Median Age | 46 | 36 | 38.4 |
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| Population - 2010 | 23,122 | 23,959 | 309,327,143 |
| Population - 2000 | 21,823 | 20,559 | 285,036,114 |
| Population - 1990 | 18,885 | 16,569 | 251,960,433 |
| Pop. 2000 to Now | 13.5% | 21.7% | 15.6% |
| Pop. 1990 to Now | 31.1% | 51.0% | 30.8% |
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| Population Density | 536.2 | 2,168.8 | 93.4 |
| Land Area | 46.3 | 11.6 | 3,531,905.4 |
| Water Area | 0.7 | 0.8 | 264,836.8 |
| space | | | |
| Est. Total Population By Age | | | |
| | Mequon, WI | De Pere, WI | United States |
| Age 0 to 4 | 6.3% | 4.5% | 5.9% |
| Age 5 to 9 | 5.2% | 6.3% | 6.1% |
| Age 10 to 14 | 6.9% | 6.4% | 6.6% |
| Age 15 to 17 | 5.0% | 4.4% | 3.9% |
| Age 18 to 20 | 6.9% | 8.2% | 4.0% |
| Age 21 to 24 | 3.0% | 5.3% | 5.2% |
| Age 25 to 34 | 5.6% | 13.6% | 13.8% |
| Age 35 to 44 | 10.1% | 12.1% | 12.9% |
| Age 45 to 54 | 13.6% | 11.4% | 12.6% |
| Age 55 to 59 | 7.3% | 6.3% | 6.7% |
| Age 60 to 64 | 7.8% | 5.6% | 6.3% |
| Age 65 to 74 | 12.6% | 9.8% | 9.6% |
| Age 75 to 84 | 6.6% | 3.6% | 4.5% |
| Age 85 and over | 3.0% | 2.4% | 1.9% |
| space1 | | | |
| Race | | | |
| | Mequon, WI | De Pere, WI | United States |
| White | 87.1% | 89.5% | 59.4% |
| Black | 1.8% | 0.9% | 12.2% |
| Asian | 3.5% | 4.3% | 5.6% |
| Native American | 0.1% | 1.3% | 0.6% |
| Hawaiian, Pacific Islander | 0.1% | 0.0% | 0.2% |
| Other | 0.0% | 0.0% | 0.4% |
| Two or More Races | 3.0% | 2.5% | 3.2% |
| Hispanic | 4.4% | 1.6% | 18.4% |
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| Marriage & Family | | | |
| | Mequon, WI | De Pere, WI | United States |
| Married Population | 63.3% | 50.1% | 49.8% |
| Currently Married | 62.6% | 49.7% | 48.0% |
| Married but Separated | 0.6% | 0.4% | 1.8% |
| Single Population | 36.8% | 49.9% | 50.2% |
| Never Married | 24.9% | 32.8% | 33.8% |
| Divorced | 6.9% | 11.9% | 10.8% |
| Widowed | 5.0% | 5.3% | 5.6% |
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| Household Size | 2.63 | 2.33 | 2.60 |
| Households | 8,862 | 9,946 | 124,010,992 |
| Family Households | 7,013 | 6,615 | 80,755,759 |
| Married couple, w/children | 34.3% | 33.3% | 30.5% |
| Married couple, no children | 52.1% | 42.7% | 42.9% |
| Non Family Households | 1,849 | 3,331 | 43,255,233 |
| Single householder, w/children | 8.8% | 14.8% | 15.8% |
| Single householder, no children | 4.9% | 9.2% | 10.8% |