| | Santa Clarita, CA | Mesquite, NV | United States |
| Population | 227,182 | 20,019 | 329,725,481 |
| Female Population | 50.2% | 49.6% | 50.5% |
| Male Population | 49.8% | 50.4% | 49.5% |
| Median Age | 37 | 59.7 | 38.4 |
| space3 | | | |
| Population - 2010 | 208,802 | 15,305 | 309,327,143 |
| Population - 2000 | 151,088 | 9,389 | 285,036,114 |
| Population - 1990 | 110,642 | 1,871 | 251,960,433 |
| Pop. 2000 to Now | 39.0% | 117.7% | 15.6% |
| Pop. 1990 to Now | 89.8% | 992.4% | 30.8% |
| space4 | | | |
| Population Density | 3,448.2 | 633.9 | 93.4 |
| Land Area | 65.9 | 31.6 | 3,531,905.4 |
| Water Area | 0.1 | 0.4 | 264,836.8 |
| space | | | |
| Est. Total Population By Age | | | |
| | Santa Clarita, CA | Mesquite, NV | United States |
| Age 0 to 4 | 7.1% | 4.1% | 5.9% |
| Age 5 to 9 | 6.6% | 4.2% | 6.1% |
| Age 10 to 14 | 7.9% | 5.0% | 6.6% |
| Age 15 to 17 | 4.6% | 2.6% | 3.9% |
| Age 18 to 20 | 3.6% | 2.1% | 4.0% |
| Age 21 to 24 | 4.6% | 2.2% | 5.2% |
| Age 25 to 34 | 12.8% | 7.4% | 13.8% |
| Age 35 to 44 | 13.6% | 8.6% | 12.9% |
| Age 45 to 54 | 14.5% | 9.4% | 12.6% |
| Age 55 to 59 | 6.7% | 5.0% | 6.7% |
| Age 60 to 64 | 6.3% | 7.4% | 6.3% |
| Age 65 to 74 | 7.1% | 24.9% | 9.6% |
| Age 75 to 84 | 3.3% | 14.0% | 4.5% |
| Age 85 and over | 1.3% | 3.1% | 1.9% |
| space1 | | | |
| Race | | | |
| | Santa Clarita, CA | Mesquite, NV | United States |
| White | 45.1% | 65.2% | 59.4% |
| Black | 3.9% | 1.0% | 12.2% |
| Asian | 10.2% | 2.2% | 5.6% |
| Native American | 0.2% | 0.9% | 0.6% |
| Hawaiian, Pacific Islander | 0.4% | 0.6% | 0.2% |
| Other | 0.5% | 0.1% | 0.4% |
| Two or More Races | 4.3% | 1.7% | 3.2% |
| Hispanic | 35.4% | 28.2% | 18.4% |
| space2 | | | |
| Marriage & Family | | | |
| | Santa Clarita, CA | Mesquite, NV | United States |
| Married Population | 54.2% | 61.1% | 49.8% |
| Currently Married | 52.6% | 59.3% | 48.0% |
| Married but Separated | 1.7% | 1.8% | 1.8% |
| Single Population | 45.8% | 38.9% | 50.2% |
| Never Married | 32.6% | 18.9% | 33.8% |
| Divorced | 8.9% | 11.0% | 10.8% |
| Widowed | 4.3% | 9.0% | 5.6% |
| space5 | | | |
| Household Size | 3.07 | 2.34 | 2.60 |
| Households | 73,294 | 8,522 | 124,010,992 |
| Family Households | 55,611 | 5,921 | 80,755,759 |
| Married couple, w/children | 39.2% | 14.8% | 30.5% |
| Married couple, no children | 38.6% | 68.9% | 42.9% |
| Non Family Households | 17,683 | 2,601 | 43,255,233 |
| Single householder, w/children | 11.7% | 8.7% | 15.8% |
| Single householder, no children | 10.6% | 7.6% | 10.8% |