| | Clarksdale, MS | Brandon, MS | United States |
| Population | 15,124 | 24,887 | 329,725,481 |
| Female Population | 52.9% | 51.3% | 50.5% |
| Male Population | 47.1% | 48.7% | 49.5% |
| Median Age | 35.2 | 41.7 | 38.4 |
| space3 | | | |
| Population - 2010 | 17,926 | 22,096 | 309,327,143 |
| Population - 2000 | 20,645 | 16,436 | 285,036,114 |
| Population - 1990 | 19,717 | 11,077 | 251,960,433 |
| Pop. 2000 to Now | -29.9% | 48.4% | 15.6% |
| Pop. 1990 to Now | -26.6% | 120.2% | 30.8% |
| space4 | | | |
| Population Density | 1,089.1 | 969.8 | 93.4 |
| Land Area | 13.9 | 25.7 | 3,531,905.4 |
| Water Area | 0.0 | 0.1 | 264,836.8 |
| space | | | |
| Est. Total Population By Age | | | |
| | Clarksdale, MS | Brandon, MS | United States |
| Age 0 to 4 | 8.1% | 5.3% | 5.9% |
| Age 5 to 9 | 6.7% | 6.3% | 6.1% |
| Age 10 to 14 | 7.5% | 8.7% | 6.6% |
| Age 15 to 17 | 4.5% | 3.1% | 3.9% |
| Age 18 to 20 | 5.8% | 3.6% | 4.0% |
| Age 21 to 24 | 4.9% | 4.8% | 5.2% |
| Age 25 to 34 | 12.4% | 9.3% | 13.8% |
| Age 35 to 44 | 11.3% | 14.5% | 12.9% |
| Age 45 to 54 | 10.0% | 15.6% | 12.6% |
| Age 55 to 59 | 5.7% | 4.5% | 6.7% |
| Age 60 to 64 | 7.0% | 6.7% | 6.3% |
| Age 65 to 74 | 10.1% | 10.6% | 9.6% |
| Age 75 to 84 | 3.7% | 5.7% | 4.5% |
| Age 85 and over | 2.4% | 1.3% | 1.9% |
| space1 | | | |
| Race | | | |
| | Clarksdale, MS | Brandon, MS | United States |
| White | 16.2% | 77.1% | 59.4% |
| Black | 81.2% | 19.6% | 12.2% |
| Asian | 0.7% | 0.1% | 5.6% |
| Native American | 0.2% | 0.1% | 0.6% |
| Hawaiian, Pacific Islander | 0.0% | 0.0% | 0.2% |
| Other | 0.1% | 0.3% | 0.4% |
| Two or More Races | 1.0% | 0.3% | 3.2% |
| Hispanic | 0.5% | 2.5% | 18.4% |
| space2 | | | |
| Marriage & Family | | | |
| | Clarksdale, MS | Brandon, MS | United States |
| Married Population | 30.9% | 62.0% | 49.8% |
| Currently Married | 25.7% | 60.2% | 48.0% |
| Married but Separated | 5.3% | 1.8% | 1.8% |
| Single Population | 69.1% | 38.0% | 50.2% |
| Never Married | 50.2% | 22.1% | 33.8% |
| Divorced | 9.4% | 9.9% | 10.8% |
| Widowed | 9.4% | 6.0% | 5.6% |
| space5 | | | |
| Household Size | 2.57 | 2.67 | 2.60 |
| Households | 5,752 | 8,955 | 124,010,992 |
| Family Households | 3,539 | 6,804 | 80,755,759 |
| Married couple, w/children | 11.2% | 36.0% | 30.5% |
| Married couple, no children | 27.2% | 46.4% | 42.9% |
| Non Family Households | 2,213 | 2,151 | 43,255,233 |
| Single householder, w/children | 41.6% | 10.5% | 15.8% |
| Single householder, no children | 20.0% | 7.1% | 10.8% |