| | De Pere, WI | La Crosse, WI | United States |
| Population | 25,216 | 52,505 | 329,725,481 |
| Female Population | 53.5% | 51.6% | 50.5% |
| Male Population | 46.5% | 48.4% | 49.5% |
| Median Age | 36 | 29.4 | 38.4 |
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| Population - 2010 | 23,959 | 51,373 | 309,327,143 |
| Population - 2000 | 20,559 | 51,818 | 285,036,114 |
| Population - 1990 | 16,569 | 51,003 | 251,960,433 |
| Pop. 2000 to Now | 21.7% | -1.3% | 15.6% |
| Pop. 1990 to Now | 51.0% | 0.3% | 30.8% |
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| Population Density | 2,168.8 | 2,416.7 | 93.4 |
| Land Area | 11.6 | 21.7 | 3,531,905.4 |
| Water Area | 0.8 | 2.1 | 264,836.8 |
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| Est. Total Population By Age | | | |
| | De Pere, WI | La Crosse, WI | United States |
| Age 0 to 4 | 4.5% | 4.6% | 5.9% |
| Age 5 to 9 | 6.3% | 3.6% | 6.1% |
| Age 10 to 14 | 6.4% | 4.7% | 6.6% |
| Age 15 to 17 | 4.4% | 2.2% | 3.9% |
| Age 18 to 20 | 8.2% | 14.0% | 4.0% |
| Age 21 to 24 | 5.3% | 13.3% | 5.2% |
| Age 25 to 34 | 13.6% | 15.0% | 13.8% |
| Age 35 to 44 | 12.1% | 9.8% | 12.9% |
| Age 45 to 54 | 11.4% | 8.0% | 12.6% |
| Age 55 to 59 | 6.3% | 5.0% | 6.7% |
| Age 60 to 64 | 5.6% | 4.8% | 6.3% |
| Age 65 to 74 | 9.8% | 8.1% | 9.6% |
| Age 75 to 84 | 3.6% | 4.0% | 4.5% |
| Age 85 and over | 2.4% | 2.9% | 1.9% |
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| Race | | | |
| | De Pere, WI | La Crosse, WI | United States |
| White | 89.5% | 88.4% | 59.4% |
| Black | 0.9% | 2.2% | 12.2% |
| Asian | 4.3% | 4.1% | 5.6% |
| Native American | 1.3% | 0.3% | 0.6% |
| Hawaiian, Pacific Islander | 0.0% | 0.0% | 0.2% |
| Other | 0.0% | 0.1% | 0.4% |
| Two or More Races | 2.5% | 2.5% | 3.2% |
| Hispanic | 1.6% | 2.4% | 18.4% |
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| Marriage & Family | | | |
| | De Pere, WI | La Crosse, WI | United States |
| Married Population | 50.1% | 29.4% | 49.8% |
| Currently Married | 49.7% | 28.5% | 48.0% |
| Married but Separated | 0.4% | 0.9% | 1.8% |
| Single Population | 49.9% | 70.6% | 50.2% |
| Never Married | 32.8% | 54.1% | 33.8% |
| Divorced | 11.9% | 10.7% | 10.8% |
| Widowed | 5.3% | 5.7% | 5.6% |
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| Household Size | 2.33 | 2.17 | 2.60 |
| Households | 9,946 | 22,117 | 124,010,992 |
| Family Households | 6,615 | 9,475 | 80,755,759 |
| Married couple, w/children | 33.3% | 27.1% | 30.5% |
| Married couple, no children | 42.7% | 38.8% | 42.9% |
| Non Family Households | 3,331 | 12,642 | 43,255,233 |
| Single householder, w/children | 14.8% | 19.5% | 15.8% |
| Single householder, no children | 9.2% | 14.6% | 10.8% |