| | Iowa City, IA | Santa Ana, CA | United States |
| Population | 74,240 | 313,818 | 329,725,481 |
| Female Population | 50.0% | 48.6% | 50.5% |
| Male Population | 50.0% | 51.4% | 49.5% |
| Median Age | 26.1 | 33 | 38.4 |
| space3 | | | |
| Population - 2010 | 68,053 | 325,069 | 309,327,143 |
| Population - 2000 | 62,220 | 337,977 | 285,036,114 |
| Population - 1990 | 59,738 | 293,742 | 251,960,433 |
| Pop. 2000 to Now | 23.1% | -2.0% | 15.6% |
| Pop. 1990 to Now | 28.2% | 12.8% | 30.8% |
| space4 | | | |
| Population Density | 2,901.3 | 11,469.5 | 93.4 |
| Land Area | 25.6 | 27.4 | 3,531,905.4 |
| Water Area | 0.5 | 0.0 | 264,836.8 |
| space | | | |
| Est. Total Population By Age | | | |
| | Iowa City, IA | Santa Ana, CA | United States |
| Age 0 to 4 | 4.3% | 6.4% | 5.9% |
| Age 5 to 9 | 3.8% | 6.5% | 6.1% |
| Age 10 to 14 | 4.1% | 7.6% | 6.6% |
| Age 15 to 17 | 2.3% | 4.4% | 3.9% |
| Age 18 to 20 | 15.1% | 4.6% | 4.0% |
| Age 21 to 24 | 18.1% | 6.4% | 5.2% |
| Age 25 to 34 | 15.0% | 16.7% | 13.8% |
| Age 35 to 44 | 9.9% | 14.1% | 12.9% |
| Age 45 to 54 | 8.4% | 12.8% | 12.6% |
| Age 55 to 59 | 3.4% | 5.9% | 6.7% |
| Age 60 to 64 | 4.4% | 4.5% | 6.3% |
| Age 65 to 74 | 6.9% | 6.1% | 9.6% |
| Age 75 to 84 | 2.6% | 2.4% | 4.5% |
| Age 85 and over | 1.5% | 1.4% | 1.9% |
| space1 | | | |
| Race | | | |
| | Iowa City, IA | Santa Ana, CA | United States |
| White | 73.8% | 9.5% | 59.4% |
| Black | 8.2% | 0.9% | 12.2% |
| Asian | 7.7% | 11.8% | 5.6% |
| Native American | 0.1% | 0.1% | 0.6% |
| Hawaiian, Pacific Islander | 0.1% | 0.2% | 0.2% |
| Other | 0.4% | 0.1% | 0.4% |
| Two or More Races | 3.5% | 0.8% | 3.2% |
| Hispanic | 6.4% | 76.7% | 18.4% |
| space2 | | | |
| Marriage & Family | | | |
| | Iowa City, IA | Santa Ana, CA | United States |
| Married Population | 34.9% | 45.8% | 49.8% |
| Currently Married | 34.5% | 43.8% | 48.0% |
| Married but Separated | 0.4% | 2.0% | 1.8% |
| Single Population | 65.1% | 54.2% | 50.2% |
| Never Married | 56.6% | 42.7% | 33.8% |
| Divorced | 5.9% | 7.5% | 10.8% |
| Widowed | 2.6% | 3.9% | 5.6% |
| space5 | | | |
| Household Size | 2.25 | 4.04 | 2.60 |
| Households | 30,380 | 76,624 | 124,010,992 |
| Family Households | 12,704 | 61,790 | 80,755,759 |
| Married couple, w/children | 32.6% | 37.9% | 30.5% |
| Married couple, no children | 48.8% | 30.2% | 42.9% |
| Non Family Households | 17,676 | 14,834 | 43,255,233 |
| Single householder, w/children | 10.5% | 17.2% | 15.8% |
| Single householder, no children | 8.1% | 14.6% | 10.8% |