| | Rochester, MN | Mexico, MO | United States |
| Population | 119,732 | 11,592 | 329,725,481 |
| Female Population | 50.9% | 51.8% | 50.5% |
| Male Population | 49.1% | 48.2% | 49.5% |
| Median Age | 36.1 | 37.6 | 38.4 |
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| Population - 2010 | 107,050 | 11,517 | 309,327,143 |
| Population - 2000 | 85,806 | 11,320 | 285,036,114 |
| Population - 1990 | 70,745 | 11,290 | 251,960,433 |
| Pop. 2000 to Now | 39.7% | 1.9% | 15.6% |
| Pop. 1990 to Now | 69.4% | 2.1% | 30.8% |
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| Population Density | 2,169.3 | 956.9 | 93.4 |
| Land Area | 55.2 | 12.1 | 3,531,905.4 |
| Water Area | 0.3 | 0.4 | 264,836.8 |
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| Est. Total Population By Age | | | |
| | Rochester, MN | Mexico, MO | United States |
| Age 0 to 4 | 7.1% | 7.4% | 5.9% |
| Age 5 to 9 | 6.5% | 5.4% | 6.1% |
| Age 10 to 14 | 6.7% | 5.6% | 6.6% |
| Age 15 to 17 | 3.9% | 4.4% | 3.9% |
| Age 18 to 20 | 2.8% | 2.8% | 4.0% |
| Age 21 to 24 | 5.3% | 4.6% | 5.2% |
| Age 25 to 34 | 15.9% | 16.4% | 13.8% |
| Age 35 to 44 | 13.9% | 11.9% | 12.9% |
| Age 45 to 54 | 11.0% | 10.8% | 12.6% |
| Age 55 to 59 | 6.7% | 7.5% | 6.7% |
| Age 60 to 64 | 5.3% | 6.5% | 6.3% |
| Age 65 to 74 | 8.4% | 9.7% | 9.6% |
| Age 75 to 84 | 4.3% | 4.6% | 4.5% |
| Age 85 and over | 2.3% | 2.6% | 1.9% |
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| Race | | | |
| | Rochester, MN | Mexico, MO | United States |
| White | 73.5% | 84.4% | 59.4% |
| Black | 8.8% | 5.3% | 12.2% |
| Asian | 7.2% | 0.5% | 5.6% |
| Native American | 0.1% | 0.3% | 0.6% |
| Hawaiian, Pacific Islander | 0.1% | 0.2% | 0.2% |
| Other | 0.3% | 0.1% | 0.4% |
| Two or More Races | 4.1% | 6.0% | 3.2% |
| Hispanic | 5.8% | 3.2% | 18.4% |
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| Marriage & Family | | | |
| | Rochester, MN | Mexico, MO | United States |
| Married Population | 52.8% | 42.3% | 49.8% |
| Currently Married | 51.7% | 41.0% | 48.0% |
| Married but Separated | 1.2% | 1.3% | 1.8% |
| Single Population | 47.2% | 57.7% | 50.2% |
| Never Married | 33.3% | 30.5% | 33.8% |
| Divorced | 9.2% | 19.4% | 10.8% |
| Widowed | 4.7% | 7.8% | 5.6% |
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| Household Size | 2.40 | 2.61 | 2.60 |
| Households | 48,990 | 4,345 | 124,010,992 |
| Family Households | 29,489 | 2,719 | 80,755,759 |
| Married couple, w/children | 34.6% | 23.6% | 30.5% |
| Married couple, no children | 44.8% | 41.0% | 42.9% |
| Non Family Households | 19,501 | 1,626 | 43,255,233 |
| Single householder, w/children | 15.3% | 22.3% | 15.8% |
| Single householder, no children | 5.3% | 13.2% | 10.8% |