| | Manhattan, KS | Medford, OR | United States |
| Population | 54,794 | 84,894 | 329,725,481 |
| Female Population | 49.0% | 50.6% | 50.5% |
| Male Population | 51.0% | 49.4% | 49.5% |
| Median Age | 25 | 37.7 | 38.4 |
| space3 | | | |
| Population - 2010 | 52,531 | 75,066 | 309,327,143 |
| Population - 2000 | 44,831 | 63,154 | 285,036,114 |
| Population - 1990 | 37,712 | 46,951 | 251,960,433 |
| Pop. 2000 to Now | 22.6% | 32.1% | 15.6% |
| Pop. 1990 to Now | 45.7% | 77.7% | 30.8% |
| space4 | | | |
| Population Density | 2,762.9 | 3,295.3 | 93.4 |
| Land Area | 19.8 | 25.8 | 3,531,905.4 |
| Water Area | 0.1 | 0.0 | 264,836.8 |
| space | | | |
| Est. Total Population By Age | | | |
| | Manhattan, KS | Medford, OR | United States |
| Age 0 to 4 | 4.5% | 6.2% | 5.9% |
| Age 5 to 9 | 3.6% | 6.3% | 6.1% |
| Age 10 to 14 | 4.4% | 7.1% | 6.6% |
| Age 15 to 17 | 2.7% | 3.9% | 3.9% |
| Age 18 to 20 | 15.8% | 3.1% | 4.0% |
| Age 21 to 24 | 19.0% | 4.9% | 5.2% |
| Age 25 to 34 | 15.9% | 14.8% | 13.8% |
| Age 35 to 44 | 9.8% | 13.2% | 12.9% |
| Age 45 to 54 | 7.4% | 11.0% | 12.6% |
| Age 55 to 59 | 3.5% | 5.5% | 6.7% |
| Age 60 to 64 | 4.4% | 6.2% | 6.3% |
| Age 65 to 74 | 5.4% | 10.3% | 9.6% |
| Age 75 to 84 | 2.1% | 4.9% | 4.5% |
| Age 85 and over | 1.5% | 2.8% | 1.9% |
| space1 | | | |
| Race | | | |
| | Manhattan, KS | Medford, OR | United States |
| White | 76.5% | 74.9% | 59.4% |
| Black | 5.6% | 0.9% | 12.2% |
| Asian | 5.3% | 1.1% | 5.6% |
| Native American | 0.4% | 1.0% | 0.6% |
| Hawaiian, Pacific Islander | 0.2% | 0.3% | 0.2% |
| Other | 0.2% | 0.2% | 0.4% |
| Two or More Races | 4.2% | 4.4% | 3.2% |
| Hispanic | 7.6% | 17.2% | 18.4% |
| space2 | | | |
| Marriage & Family | | | |
| | Manhattan, KS | Medford, OR | United States |
| Married Population | 33.3% | 48.9% | 49.8% |
| Currently Married | 32.5% | 47.2% | 48.0% |
| Married but Separated | 0.8% | 1.6% | 1.8% |
| Single Population | 66.7% | 51.1% | 50.2% |
| Never Married | 55.3% | 30.0% | 33.8% |
| Divorced | 8.6% | 15.0% | 10.8% |
| Widowed | 2.8% | 6.2% | 5.6% |
| space5 | | | |
| Household Size | 2.35 | 2.47 | 2.60 |
| Households | 20,815 | 33,645 | 124,010,992 |
| Family Households | 9,641 | 20,673 | 80,755,759 |
| Married couple, w/children | 28.3% | 31.4% | 30.5% |
| Married couple, no children | 46.5% | 40.9% | 42.9% |
| Non Family Households | 11,174 | 12,972 | 43,255,233 |
| Single householder, w/children | 20.4% | 18.5% | 15.8% |
| Single householder, no children | 4.8% | 9.1% | 10.8% |